Introduction. Part A: Cytokines and their Receptors in the Liver. Section 1: Regulation of Synthesis. 1. Cytokine response to infection; A. Cerami. 2. Interleukin-8 and other chemokines: new perspectives in inflammation; M. Baggiolini, M. Uguccioni, M. d'Apuzzo. 3. Induction of IL-1ra synthesis by hepatic acute phase proteins; J.W. Mier. 4. IL-6 signal transduction from the plasma membrane to the nucleus; F. Horn, C. Lutticken, U. Wegenka, J. Yuan, P.C. Heinrich. Section II: Signal Transduction Pathways and Effects. 5. Activation of NH-kappa-B and AP-1 in rat Kupffer cells; T.A. Tran-Thi, K. Decker, P.A. Bauerle. 6. Cytokines and adhesion molecules in the liver; K. Tanikawa. 7. Regulation and functional implications of hepatic NO synthesis from L-arginine; A. Mulsch. Part B: Cell Biological Aspects. Section III: Inflammation and Fibrogenesis. 8. Production of inflammatory cytokines by Kupffer cells: evidence for autocrine and paracrine regulatory mechanisms; M. Grewe. 9. Role of sinusoidal endothelial cells in liver fibrosis; G. Ramadori, K. Neubauer. 10. The contribution of hepatocytes to cytokine-directed activation of fat-storing cells -- a pathogenetic key mechanism in liver fibrogenesis; A.M. Gressner, C. Hoffman, M.G. Bachem, G. Schuftan, B. Lahme, A. Brenzel. Section IV: Function of Stellate Cells and Growth Regulation. 11. On the contraction and relaxation of stellate cells induced by Kupffer cell-derived vasoactive substances; N. Kawada, K. Decker. 12. The initiation of liver regeneration and the regulation of liver growth by transforming growth factor alpha (TGF alpha); N. Fausto. 13. Role of HGF in liver regeneration; G.K. Michalopoulos, W.M. Mars, M-L. Liu. Part C: Clinical Implications. Section V: Hepatitis and Cirrhosis. 14. Kupffer cell processing of bacterial lipopolysaccharide; E.S. Fox, P. Thomas. 15. Cytokines in alcoholic liver cirrhosis; J. Deviere, O. Le Moine, M. Goldman, E. Dupont. 16. Autoimmune hepatitis and cytokines; C. Trautwein, M.P. Manns. 17. Cytokine profiles in primary biliary cirrhosis: an approach to define the underlying immunoreactivity; P.A. Berg, R. Klein, M. Leuschner, U. Leuschner. Section VI: Responses of the Challenged Liver. 18. Growth factors in liver disease; W.E. Fleig. 19. Cytokine regulation of hepatic acute phase protein expression; Z. Xing, C.D. Richards, T. Braciak, V. Thibault, J. Gauldie. 20. Cytokine-induced alterations in hepatic lipid metabolism; K.R. Feingold, I. Hardardottir, C. Grunfeld. Section VII: Liver Transplantation. 21. Cytokines in liver transplantation and alcoholic liver disease; R.G. Thurman, E. Savier, Y. Adachi, S.I. Shedlofsky, J.J. Lemasters, W. Gao, B.U. Bradford, Z. Zhong, K.T. Knecht, W. Qu, R.T. Currin, S. Lichtman, J. Wang, M. Goto. 22. Role of cytokines in the regulation of cell-cell and cell-matrix adhesion molecules in human liver transplants; G. Steinhoff. 23. Cytokines in liver allograft rejection; A.S. Gaweco, W.J. Hofmann. Index.