Cyclosporin : Mode of Action and Clinical Application

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Cyclosporin has had a remarkable effect on clinical organ transplantation. Prior to its introduction, considerable advances had been made in the grafting of vital organs, particularly the kidney, heart and liver. In many developed countries, however, transplantation was not considered wo-rthwhile in terms of gain for the investment of resources. The improved results of kidney grafts following the use of cyclosporin has changed this attitude. For all types of organ transplantation, cyclosporin has resulted in an improvement of functional graft survival and has allowed a reduction in steroid dose and, in some cases, no steroids at all. It has permitted the first successful experimental transplantation of the heart and lungs in primate species by Reitz and colleagues and their results were applied directly to the clinic. It was largely due to the introduction of cyclosporin that the Washington Consensus Meeting on Liver Transplantation came to a favourable recommendation and the result has been the proliferation of units performing liver transplantation, approximately fifty in North America and another fifty in Europe, where previously there had been a handful. Having been involved in cyclosporin for organ grafting from the beginning, I have been able to witness these developments which have far exceeded my expectations once the nephrotoxicity of cyclosporin was demonstrated in man. It is fitting that more

Product details

  • Hardback | 384 pages
  • 160 x 233.7 x 25.4mm | 748.44g
  • Kluwer Academic Publishers Group
  • Kluwer Academic Publishers
  • Dordrecht, Netherlands
  • English
  • 1989 ed.
  • biography
  • 0746201249
  • 9780746201244

Table of contents

1 Inhibitory effects of cyclosporin A on lymphocyte activation.- 2 Effect of cyclosporin A on the immune response: pivotal role of the interleukin-2/interleukin-2 receptor autocrine pathway.- 3 Influence of cyclosporin A on humoral immunity and on B lymphocyte activation.- 4 The influence of cyclosporin A on T cell activation, cytokine gene expression and cell-mediated immunity.- 5 Cyclosporin A and tolerance induction in experimental animals.- 6 Prevention of graft rejection by cyclosporin A in man.- 7 Cyclosporin A and bone marrow transplantation.- 8 Cyclosporin A and intraocular inflammatory disease.- 9 Cyclosporin A in insulin-dependent diabetes.- 10 Cyclosporin A and skin disease.- 11 Cyclosporin A (Sandimmun®) in autoimmune disorders.- 12 Pharmacokinetics of cyclosporin A.- 13 Cyclosporin A metabolism and drug interactions.- 14 Pathological effects of cyclosporin A in experimental models.- 15 Pathological effects of cyclosporin A in clinical more