Cycloaddition Reactions in Organic Synthesis
Cycloaddition reactions are among the most important tools for synthesis in organic chemistry, since these reactions are vital to the modern synthesis of natural products and biologically active substances. Metal catalysis plays an increasingly important role in these reactions, often allowing several stereocenters to be selectively created and integrated in the target molecules. Kobayashi and Jorgensen's handbook provides numerous examples of metal-catalyzed reactions, including [2+1], [3+2] and [4+2] cycloadditions. Important reactions such as carbo- and hetero-Diels-Alder, carbocyclic, cyclopropanation and 1,3-dipolar cycloaddition reactions are discussed. A large number of experimental procedures gives a concrete idea of the use of metal-catalyzed cycloaddition reactions in modern synthesis. The book is aimed at chemists in industry or academia, who want to effectively use cycloadditions in their work.
- Hardback | 344 pages
- 172.2 x 247.4 x 21.6mm | 793.8g
- 19 Mar 2002
- Wiley-VCH Verlag GmbH
- Weinheim, Germany
Table of contents
List of Contributors. Introduction. References. Catalytic Asymmetric Diels--Alder Reactions (Yuyiro Hayashi). Recent Advances in Palladium--catalyzed Cycloadditions Involving Trimethylenemethane and its Analogs (Dominic M.T. Chan). Enantioselective [2+1] Cycloaddition: Cyclopropanation with Zinc Carbenoids (Scott E. Denmark and Gregory Beutner). Catalytic Enantioselective Cycloaddition Reactions of Carbonyl Compounds (Karl Anker Jorgensen). Catalytic Enantioselective Aza Diels--Alder Reactions (Shu Kobayashi). Ssymmetric Metal--catalyzed 1,3--Dipolar Cycloaddition eactions (Kurt Vesterager Gothelf). Aqua Complex Lewis Acid Catalysts for Asymmetric 3+2 Cycloaddition Reactions (Shuji Kanemasa). Theoretical Calculations of Metal--catalyzed Cycloaddition Reactions (Karl Anker Jorgensen). Index.
"...highly useful coverage of these rapidly expanding research areas..." (Synthesis, No.10, 2002) "...surveys the various types of meal--catalyzed cycloaddition reactions and their applications in organic synthesis." (SciTech Book News, Vol. 26, No. 2, June 2002) "...it contains a number of excellent current reciews of the subject..." (Chemistry & Industry, 4 November 2002) "...excellent book...will be appreciated by chemists in academia and industry..." (Journal of Natural Products, 2003)