Preface. List of Contributors. I: Cratine: Biochemical Aspects. Creatine-Phosphocreatine Pathway in the Intracellular Networks of Energy Transfer and Signal Transduction in Muscle Cells; V. Saks, et al. Guanidinoacetate Methyltransferase (GAMT) Deficiency, the First Inborn Error of Creatine Metabolism; S. Stockler-Ipsirogulu. II: Physiology and Physiopathology. A Physiological View of The Creatine-Phosphate Shuttle, Exercise, and Protein Synthesis; S.P. Bessman, J. Luo. Creatine in Cardiovascular Metabolism During Physiological and Pathological Conditions: NMR Studies; J.F. Clark. III: Role of Creatine in the Clinical Practice. Effects and Safety of Dietary and Supplementary Creatine; R.C. Harris. Creatine Supplementation in Patients with Chronic Heart Failure; A. Gordon. Creatine in Sports Medicine: Nutritional Supplementation and/or Medicinal Product? G. Benzi. IV: Use of Creatine in Sports Medicine. Physiological Role of Creatine in Muscle Metabolism During Exercise; P. Ruggeri. Impact of Oral Creatine Supplementation on Muscle Performance During Training and Rehabilitation; P. Hespel, et al. Factors Modifying Creatine Accumulation in Human Skeletal Muscle; P.L. Greenhaff. V: Use of Creatine: New Potential Applications. New Areas for Creatine Supplementation: Chronic Obstructive Pulmonary Disease and Geriatric Conditions; G. Enzi. Creatine Supplementation in Mitochondrial Cytopathies; J.M. Bourgeois, M.A. Tarnopolsky. The Neuroprotective Properties of Creatine in Animal Models of Neurodegenerative Diseases; R. Kaddurah-Daouk, et al.