Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds: Volume 27 : Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds
Conjugation reactions have long been associated with the detoxification of xenobiotics. Recent studies suggest that Phase II reactions are an important mechanism for the bioactivation of xenobiotics.
This special volume of Advances in Pharmacology features a two-color dust jacket.
- Hardback | 519 pages
- 154.94 x 226.06 x 40.64mm | 907.18g
- 06 Jul 1994
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
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Table of contents
C. Andersson, E. Mosialou, R. Weinander, and R. Morgenstern, Enzymology of Microsomal Glutathione S-Transferase.
B. Ketterer and L.G. Christodoulides, Enzymology of Cytosolic Glutathione S-Transferases.
A.J.L. Cooper, Enzymology of Cysteine S-Conjugate b-Lyases.
W. Dekant, S. Vamvakas,and M.W. Anders, Formation and Fate of Nephrotoxic and Cytotoxic Glutathione S-Conjugates: Cysteine Conjugate b-Lyase Pathway.
T.A. Baille and K. Kassahun, Reversibility in Glutathione-Conjugate Formation.
T.J. Monks and S.S. Lau, Glutathione Conjugation as a Mechanism for the Transport of Reactive Metabolites.
F.P. Guengerich, Metabolism and Genotoxicity of Dihaloalkanes.
R. Munday, Bioactivation of Thiols by One-Electron Oxidation.
N. Ballatori, Glutathione Mercaptides as Transport Forms of Metals.
Sulfate Conjugate-Dependent Toxicity:
C.N. Falany and T.W. Wilborn, Biochemistry of Cytosolic Sulfotransferases Involved in Bioactivation.
C.J. Michejda and M.B.K. Koepke, Carcinogen Activation by Sulfate Conjugate Formation.
Glucuronide Conjugate-Dependent Toxicity:
K.W. Bock UDP-Glucuronsyltransferases and Their Role in Metabolism and Disposition of Carcinogens.
P. Zia-Amirhosseini, H. Spahn-Langguth, and L.Z. Benet, Bioactivation of Glucuronide-Conjugate Formation. Bioactivation and Bioconversion:
P.E. Hanna, N-Acetyltransferases, O-Acetyltransferases, and N,O-Acetyltransferases: Enzymology and Bioactivation.
M.W. Anders and W. Dekant, Aminoacylases.
J.L. Hoffman, Bioactivation by S-Adenosylation, S-Methylation, or N-Methylation.
S. Vamvakas and M.W. Anders, Bioconversion of Prodrugs by Conjugate-Processing Enzymes.
"The book provides superb reading material which chemists and pharmacologists interested in the area of chemotherapy will surely enjoy reading." --JOURNAL OF PHARMACEUTICAL SCIENCES
About Ferid Murad