Congenital Malformations of the Brain

Congenital Malformations of the Brain : Pathologic, Embryologic, Clinical, Radiologic and Genetic Aspects

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Description

This multidisciplinary approach to malformations of the brain begins with definitions and then reviews normal neuroembryology and the causes of malformations (chromosomes, abnormal genes and external teratogens). Each subsequent chapter contains a synthesis of the neuropathology, embryology, neurology, radiology, genetics and possible causes and mechanisms of each malformation. The book has abundant illustrations, particularly of migration disorders.show more

Product details

  • Hardback | 465 pages
  • 182.88 x 264.16 x 27.94mm | 1,202.01g
  • Oxford University Press Inc
  • New York, United States
  • English
  • numerous halftones, line drawings, tables, bibliography
  • 0195062450
  • 9780195062458

Table of contents

Introduction. 1: Embryology of the central nervus system. 2: Causes of malformations. 3: Neural tube defect: Part I. General introduction. 4: Neural tube defect: Part II, Anencephaly and others. 5: Neural tube defect: Part III, Chiari II malformation. 6: Neural tube defectL: Part IV, Malformations associated with neural tube defect. 7: Abnormalities of the cerebral hemisphere - Introduction. 8: Holoprosencephaly: Defects of the mediobasal prosencephalon. 9: Migration disorders and cortical dysplasias of the cerebrum: Part I, Migration disorders. 10: Migration disorders and cortical dysplasias: Part II, Cortical dysplasias and ectomesodermal syndromes. 11: Crossing the midline. 12: Hydrocephalus. 13: Malformations of skull, meninges, choroid plexus and blood vessels. 14: Hamartomas. 15: Miscellaneous. 16: Prenatal acquired lesions. 17: Perinatal degenerative lesions. 18: Pathological techniques. Appendix: Malformations for which specific genes have been identifiedshow more

Review quote

"Although multiauthored, this text flows well and is consistent in its various sections....The gross and microscopic illustrations are abundant and of high quality. They cover an amazing spectrum of malformations....The extensive clinical information will be very useful to clinicians who treat patients with congenital malformations."--Journal of Neuropathology and Experimental Neurology"This work originates with the prolific Vancouver group and is 'meant to be of practical help' to those interested in the pathology, embryology, clinical aspects, radiology, and genetics of CNS malformations. A daunting undertaking, the authors have nonetheless risen to it. Pathologists experienced mostly with adult material and basic researchers searching for a succinct source of information will benefit from the book. Clinicians will value the application of imaging techniques and discussions of diagnosis and counseling. Subspecialist too will find the book valuable, as reviews, including those of rare disorders, are impressively detailed."--Pediatric Pathology"Provides immense help and guidance to clinicians, radiologists, geneticists, and, of course, both general pathologists and neuropathologists in evaluation of patients during life and after death....Every pathology trainee should be given a copy on the first day of residency."-- Neurology"Should definitely be consulted by all those physicians who interpret ultrasound and perinatal magnetic resonance imaging scans. Its contents must be engraved in the minds and eyes of practicing pediatric neurologists, and it should at least be on the shelf of many neuroscientists."--Modern Pathology"In this excellent and ambitious book, the authors attempt to give a very comprehensive review of developmental brain malformations, including the embryological and genetic bases for the disorders, the typical clinical presentation, most common radiological manifestations, and the gross and microscopic findings....This is a superb book and a "must read" for any physician who deals with developmental malformations of the brain on a regular basis or who is interested in normal and abnormal brain development."--Annals of Neurologyshow more