Concise Guide to Drug Interaction Principles for Medical Practice

Concise Guide to Drug Interaction Principles for Medical Practice : Cytochrome P450, UGTs, P-glycoproteins

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Description

An understanding of drug interactions has become essential to the practice of medicine. Since publication of the first edition of this Concise Guide in 2001, our increasing pharmacopoeia?A?A?A?A?A?A?A?Acoupled with prolonged human life spans?A?A?A?A?A?A?A?Ahas made polypharmacy commonplace. Like the first edition of this unique pocket reference, the Second Edition is written expressly for clinicians. With four new contributors, this bestseller includes expanded sections on both phase I and phase II metabolism, updates of existing chapters and tables, new graphics, and extensive Web site references. Brand-new chapters discuss P-glycoproteins, "minor" cytochrome P450 enzymes, pain management with narcotic and nonnarcotic analgesics, prescribing guidelines, and medicolegal issues. This exceptionally practical guide is divided into four parts: 1. An easy-to-read, succinct review of pharmacology, written with clinicians in mind, explaining the importance of understanding our metabolic system and pharmacokinetics and P-glycoprotein drug interactions. 2. Thorough, carefully referenced reviews of the most clinically relevant phase I and phase II metabolic enzymes highlighted with newly expanded tables and study cases. 3. A section unique to this book on drug interactions by medical specialty, with drug tables arranged by how they are used in specialties such as gynecology, infectious diseases, internal medicine, neurology, oncology, psychiatry, and pain medicine. 4. Chapters on practical matters: prescribing guidelines, how to identify drug interaction patterns, strategies for reviewing the current literature, and medicolegal concerns. Enhanced by detailed descriptions and clinically based explanations, and complemented by a unique pocket guide to the most common and potent inhibitors and inducers of drug metabolism, this updated concise "how-to" guide will prove indispensable for busy students, teachers, and practitioners in all medically specialties.show more

Product details

  • Paperback | 425 pages
  • 109.2 x 162.6 x 33mm | 521.64g
  • American Psychiatric Association Publishing
  • American Psychiatric Press Inc.
  • VA, United States
  • English
  • Revised
  • 2nd Revised edition
  • references, index
  • 1585621110
  • 9781585621118

Table of contents

Introduction and Basic Pharmacology of Metabolic Drug Interactions. Introduction to drug interactions and to this concise guide. Definitions and phase I metabolism. Metabolism in depth: phase II. P-Glycoproteins. P450 Enzymes. 2D6. 3A4. 1A2. 2C9. 2C19. 2E1. P450 enzymes: 2A6, 2B6, 2C8. Drug Interactions by Medical Specialty. Gynecology: oral contraceptives. Internal medicine. Infectious diseases. Neurology. Oncology. Pain management I: nonnarcotic analgesics. Pain management II: narcotic analgesics. Psychiatry. Transplant surgery/rheumatology: immunosuppressants. Practical Matters. Guidelines. Medicolegal implications of drug-drug interactions. How to retrieve and review the literature. Appendix: trade and generic names used in this book. Index. Pull-out guide.show more

About Kelly L. Cozza

Kelly L. Cozza, M.D., is a Psychiatrist at the Infectious Disease Service, Department of Medicine, at the Walter Reed Army Medical Center in Washington, D.C.; Assistant Professor at the Department of Psychiatry, Uniformed Services University of the Health Sciences in Bethesda, Maryland; and Fellow of the Academy of Psychosomatic Medicine. Dr. Cozza is the Med-Psych Drug-Drug Interactions Update co-editor of Psychosomatics. Scott C. Armstrong, M.D., is Co-Medical Director at the Center for Geriatric Psychiatry, Tuality Forest Grove Hospital in Forest Grove, Oregon; Clinical Associate Professor of Psychiatry at Oregon Health and Science University in Portland; and Fellow of the American Psychiatric Association and the Academy of Psychosomatic Medicine. He has published many articles on various psychiatric subjects and is a peer reviewer for Military Medicine and Psychosomatics, as well as the Med-Psych Drug-Drug Interactions Update Editor of Psychosomatics. Jessica R. Oesterheld, M.D., is Medical Director of The Spurwink School in Portland, Maine, and an Instructor in Family Medicine at the University of New England School of Osteopathy in Biddeford, Maine.show more

Review quote

"This book presents the difficult topic of the P450 system and drug interactions in a practical, straightforward manner. Though it does become complex in some discussions of the chemical interactions, the reader should feel competent and comfortable when dealing with drug interactions of this nature after completing the book. This is an invaluable reference tool to an inpatient or consult psychiatrist, and would be a necessary addition to an outpatient psychiatrist's library. The pocket guide is helpful in providing quick reference tables of metabolizers, inducers, and inhibitors of each enzyme and medication. Finally, this second edition expanded the scope of the book and provides needed updates on new medications and research. Four Stars!"- "Brett Plyler, M.D., Doody's Health Science Book Reviews"show more