The Comprehensive Sourcebook of Bacterial Protein Toxins

The Comprehensive Sourcebook of Bacterial Protein Toxins

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The Comprehensive Sourcebook of Bacterial Protein Toxins 4th Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content.
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Product details

  • Hardback | 1200 pages
  • 154 x 232 x 64mm | 2,099.97g
  • San Diego, United States
  • English
  • 4th edition
  • 0128001887
  • 9780128001882
  • 1,763,503

Review quote

"...a comprehensive work (1,200 pages) on the subject of bacterial protein toxins. Those looking for a detailed overview are well supplied with this..." --MTA Dialog, The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition
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Table of contents

Evolutionary Aspects of Toxin-Producing Bacteria
Mobile Genetic Elements and Pathogenicity Islands Encoding Bacterial Toxins
Toxin Secretion Systems
Diphtheria Toxin
Pseudomonas aeruginosa Toxins
Bordetella Proteins Toxins
Cholera Toxin, Escherichia coli Thermolabile Enterotoxin and Other Vibrio cholerae Enterotoxins
Vibrio parahaemolyticus Virulence Determinants
Salmonella Toxin and Virulence Factors
The Shiga Toxins
Clostridial Neurotoxins: Cellular and Molecular Actions
Clostridial Neurotoxins: Uptake and Transport
Bacillus anthracis Toxins
ADP-Ribosylating Toxins Modifying the Actin Cytoskeleton
Large Clostridial Cytotoxins Modifying Small GTpases: Structure Aspects
Large Clostridial Cytotoxins Modifying Small GTpases: Cellular Aspects
Pasteurella multocida Toxin
Deamidating Toxins
Helicobaster pylori Vacuolating Toxin
Bacterial Genotoxins
Basic Mechanism of Pore-Forming Toxins
Membrane-Damaging and Cytotoxic Phospholipases
Structure and Mode of Action of RTX Toxins
Perfringolysin and Related Cholesterol-Dependent Cytolysins
Staphylococcus aureus Alpha Toxin and Leucocidins
Structural Relationships Between Small ss-Pore-forming Toxins from Clostridium perfringens
Clostridium perfringens Enterotoxin
Bacillus cereus Enterotoxins
Bacillus Insecticidal Toxins
Escherichia coli Heat-Stable Enterotoxins
Superantigen Toxins
Clostridial Toxins in the Pathogenesis of Gangrene
Engineering of Botulinum Neurotoxins as Novel Therapeutic Tools
Engineering of Bacterial Toxins for Research and Medicine
Toxins as Tools in Cell Biology
Inhibitors of Toxin Endocytosis
Inhibitors of Pore-Forming Toxins
Bacterial Toxins as Biological Weapons
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About Joseph E. Alouf

Joseph E. Alouf is Professor of Microbiology at the Pasteur Institute of Lille. He is former Head of the Department of Bacteriology and Mycology at the Pasteur Institute at Paris and Chairman of its Scientific Council. He served as Secretary General of the French Society of Immunology from 1984-1986 and President of the Federation of the European Microbiological Societies from 1989-1992. His 40-year research work relates to the field of bacterial protein toxins and immunology of infectious diseases. He is also the co-editor of several books. Daniel Ladant is Director of Research at French CNRS (National Center for Scientific Research) and head of the "Biochemistry of Macromolecular Interactions" unit at Institut Pasteur, Paris, France. He obtained a Ph.D. in Microbiology in 1989 and a " Habilitation a Diriger des Recherches " (HDR), in 1999 from the Universite Paris Diderot, Paris, France. His research has been mainly focused on the study of the molecular mechanisms that underlie protein-protein and protein-membrane interactions, using as a model system a bacterial toxin, the adenylate cyclase (CyaA) produced by Bordetella pertussis, the causative agent of whooping cough. CyaA is an essential virulence factor from B. pertussis, and belongs to the large family of RTX (Repeat in ToXins) cytolysins produced by diverse Gram-negative bacteria. By combining molecular genetics, biochemical and biophysical approaches, he has characterized the structure, function and biogenesis of the CyaA toxin, with a particular emphasis on deciphering the molecular basis of its original entry pathway that involves a direct translocation of its catalytic domain across the plasma membrane. Basic knowledge gained on the mechanisms of CyaA entry into eukaryotic target cells and its interaction with cellular effectors has been used to develop various applications in vaccinology and biotechnology. In particular, the natural property of the CyaA toxin to target immune cells has been exploited to create innovative vaccines capable of stimulating potent cell-mediated immune responses against specific antigens. Two CyaA-based recombinant vaccines are currently evaluated in clinical trials. D. Ladant also designed a CyaA-based two-hybrid (BACTH) technology that has been exploited for studying, in bacteria, the assembly of protein complexes, and particularly to analyze membrane associated machineries such as bacterial secretion systems or the bacterial cell division apparatus. His other research interests include the other class II bacterial adenylate cyclase toxins, such as Edema Factor (EF) from Bacillus anthracis and ExoY toxin from Pseudomonas aeruginosa, in particular to explore of the allosteric mechanisms implicated in the activation of these enzymes by eukaryotic factors. He has published more than 90 articles in peer-reviewed journals, 20 review articles or Book chapters and co-authored 11 patents. Michel R. Popoff, D.V.M., Ph.D. (Microbiology) from the University of Paris (1985), Habilitation a Diriger des Recherches (HDR) from the University of Paris (1990), is the Head of the Anaerobic Bacteria and Toxins Unit and the Director of the National Reference Center for Anaerobic Bacteria and Botulism at Pasteur Institute, Paris, France. He is member of the French Veterinary Academy. His laboratory is focused on Clostridium toxins through genetic and biological activity analysis and has investigated the regulation of toxin synthesis in Clostridium botulinum and Clostridium tetani. In the recent years, we have analyzed the molecular mechanism of the actin depolymerizing C. sordellii lethal toxin and clostridial binary toxins, the pore-forming C. perfringens epsilon toxin, and the passage of botulinum neurotoxin through the intestinal barrier. He was co-editor of the 3 edition of the Sourcebook of Bacterial Protein Toxins Academic Press (2006).
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