Comprehensive Biological Catalysis, Four-Volume Set

Comprehensive Biological Catalysis, Four-Volume Set : A Mechanistic Reference

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Comprehensive Biological Catalysis: A Mechanistic Reference offers a comprehensive review of enzyme catalysis from a chemical perspective. This multi-volume work thoroughly covers background chemistry. The first volume concentrates on reactions of electrophilic carbon, phosphorous and sulfur. Volume Two provides reactions of nucleophilic/carbanoid carbon. Volume Three highlights radical reactions and oxidation/reduction. The final volume, or the chemical lexicon, consists of clear explanations of alphabetically-arranged specialized terms and concepts. A team of highly regarded authors and editors were gathered together to contribute to a clear and consistent coverage of enzyme catalysis.
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Product details

  • Mixed media product | 1616 pages
  • 233.7 x 297.2 x 124.5mm | 5,171.01g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0126468605
  • 9780126468601

Table of contents


Volume I - Reactions of Electrophilic Carbon, Phosphorus and Sulfur:
S-Adenosylmethionine (AdoMet)-dependent Methyltransferases 1.
Prenyl Transfer and the Enzymes of Terpenoid and Steroid Biosynthesis.
Glycosol Transfer.
Mechanism of Folate-requiring Enzymes in One-carbon Metabolism.
Hydride and Alkyl Group Shifts in the Reactions of Aldehydes and Ketones.
Phosphoenolpyruvate as an Electrophile: Carboxyvinyl Transfer Reactions.
Physical Organic Chemistry of Acyl Transfer Reactions.
Catalytic Mechanisms of the Aspartic Proteinases.
The Serine Proteinases.
Cysteine Proteinases.
Zinc Proteinases.
Esterases and Lipases.
Reactions of Carbon at the Carbon Dioxide Level of Oxidation.
Transfer of the PO32 Group.
Phosphate Disesterases and Triesterases.
Catalysis of tRNA Aminoacylation by Class I and Class II Aminoacyl-tRNA Synthetases.
Thiol-disulfide Exchange of Divalent Sulfur.
Svi: Sulfotransferases.

Volume II - Reactions of Nucleophilic/Carbanionoid Carbon:
The Chemistry of Carbanions and Carbanion-like Transition States.
Inversion of Stereocenters.
Enol Chemistry and Enzymology.
Michael Additions and E1cb-like Elimination.
Reactions of Enzyme-derived Enamines.
Pyridoxal Phosphate-dependent Enzymes.
Pyruvoyl-dependent Enzymes.
Thiamin-dependent Enzymes.

Volume III - Radical Reactions and Oxidation/Reduction:
NAD+ and NADP-linked Reactions.
Flavin-dependent Enzymes.
Quinoprotein-catalysed Reactions.
The Tetrahydropterin-dependent Hydroxylases.
Heme Enzymes.
Corrin-dependent Reactions.
Catalysis by Non-heme Iron.
The Nitrogenases.
Nickel-dependent Redox Enzymes.
Molybdenum Metalloenzymes.
Copper Metalloenzymes.
Vanadium-dependent Redox Enzymes: Vanadium Haloperoxidase.
Manganese Metalloenzymes.

Volume IV - The Lexicon of Terms and Concepts in Mechanistic Enzymology and Index to Volumes I-III:
Volume IV contains substantial entries and a number of dictionary-style definitions which refer to these entries. The substantial entries are:
Affinity Labelling.
beta-Barrel Folding Pattern.
Circular Dichroism.
Diffusion Controlled Reactions.
Elementary aspects of protein structure.
EPR Spectroscopy.
General Acid-General Base Catalysis.
Introns and Exons.
Isotope Effects.
Linear Free Energy Relationships.
Moessbauer Spectroscopy.
Non-Steady State Kinetics.
Quantum Mechanical Tunnelling.
Raman and Resonance Raman Spectroscopy.
Rossmann Fold.
SQUID Magnetometry.
Steady State Kinetics.
Transition State.
Transition State Analogue.
X-ray Absorption.
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Review quote

"Having the underlying chemistry and the enzymic work alongside one another and at the most advanced level is going to be very attractive."
--D. BETHELL, University of Liverpool, U.K.
"Series shows an intelligent recognition of the frontiers as well as good authorities."
--RONALD KLUGER, University of Toronto, Canada
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About Michael Sinnott

Professor Michael J. Sinnott is a British citizen, yet is also a permanent resident of the United States. He graduated from the Honor School of Natural Science (Chemistry) Oxford University, UK in 1962. He remained there until 1966 when he moved to the University of Bristol, UK, where he carried out research work in the Department of Organic Chemistry under supervision of Professor M.C. Whiting. He was awarded aPh.D. by the University in 1969.Professor Sinnott took on postdoctoral research at Stanford University, California and the University of Bristol, before receiving the Tate and Lyle Award in Carbohydrate Chemistry for 1978 from the Chemical Society. He was promoted to a Readership in Bioorganic Chemistry at the University of Bristol in 1982, and was appointed Professor of Chemistry at the University of Illinois at Chicago in 1989. He was awarded a University of Illinois Senior Scholarship in 1993. In 1996 he took a Chair in the Department of Paper Science, University of Manchester Institute of Science and Technology.Professor Sinnott's current research interests are centered around the phenomenon of glycosyl transfer, using expertise with this type of reaction to address questions across a range of disciplines from mainstream physical organic chemistry, through enzymology to molecular evolution.
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