Clinical and Translational Science

Clinical and Translational Science : Principles of Human Research

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Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health.

This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science.
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Product details

  • Paperback | 808 pages
  • 216 x 276 x 38.1mm | 2,200g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 2nd edition
  • 150; Illustrations, unspecified
  • 0128021012
  • 9780128021019
  • 1,150,067

Table of contents

Section I. Fundamental Principles

Chapter 1. Introduction to Clinical Research

Chapter 2. Patient-Oriented Research

Chapter 3. Clinical Trials

Chapter 4. Introduction to Epidemiology

Chapter 5. The Patient-Centered Outcomes Research Institute: Current Approach to Funding Clinical Research and Future Directions

Chapter 6. Health-Care Technology Assessment (HTA)

Chapter 7. Health Services Research: Translating Discovery and Research Into Practice and Policy

Section II. Approaches

Chapter 8. Measurement of Biological Materials

Chapter 9. Imaging Tools in Clinical Research: Focus on Imaging Technologies

Chapter 10. Imaging Tools in Human Research: Focus on Image-Guided Intervention

Chapter 11. Nanotechnology in Clinical and Translational Research

Chapter 12. The Use of Questionnaires and Surveys

Chapter 13. Information Technology

Chapter 14. Principles of Biostatistics

Chapter 15. Good Clinical Practice and Good Laboratory Practice

Section III. Human Genetics

Chapter 16. Introduction to Human Genetics

Chapter 17. Epidemiologic and Population Genetic Studies

Chapter 18. Pharmacogenetics of Drug Metabolism

Chapter 19. Statistical Techniques for Genetic Analysis

Section IV. Human Pharmacology

Chapter 20. Introduction to Clinical Pharmacology

Chapter 21. Adverse Drug Events

Section V. Societal Context of Human Research

Chapter 22. Translating Science to the Bedside: The Innovation Pipeline

Chapter 23. Regulatory Environment

Chapter 24. Ethical Issues in Translational Research and Clinical Investigation

Chapter 25. Clinical Research in the Public Eye

Section VI. Research in Special Populations

Chapter 26. Research in Special Populations: Acute Illnesses; Critical Care; and Surgical Patients

Chapter 27. Research in the Emergency Care Environment

Chapter 28. Psychiatric Disorders

Chapter 29. Research in Special Populations: Geriatrics

Chapter 30. Clinical Research in Neurology

Chapter 31. Research in Pediatrics

Chapter 32. Cancer as a Paradigm for Translational and Clinical Biomedical Research

Chapter 33. Maintaining an Emphasis on Rare Diseases With Research Initiatives and Resources at the National Center for Advancing Translational Sciences

Section VII. Infrastructure

Chapter 34. Clinical and Translational Science Infrastructure

Section VIII. Education, Training and Career Choices

Chapter 35. Education, Training and Career Choices: Training Basic, Clinical, and Translational Investigators

Chapter 36. A Stepwise Approach to a Career in Translational Research

Chapter 37. Physician Careers in the Pharmaceutical Industry

Section IX. Research in Academia

Chapter 38. Industry-Sponsored Clinical Research in Academia

Chapter 39. Governmental Support of Research

Chapter 40. The Role of Nonprofit, Nongovernmental Funding in Support of Biomedical Research

Chapter 41. Modern Drug Discovery and Development

Chapter 42. Pharmaceutical and Biotechnology Sector Support of Research

Section X. Prospectus

Chapter 43. The Future of Clinical Research
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About Gordon Williams

Dr. Robertson graduated from Vanderbilt University in 1969, with a B.A. in Germanic and Slavic Languages. He attended the Arnamagnaen Institute in Copenhagen, Denmark before receiving his medical degree from Vanderbilt University Medical School in 1973. He went on to complete an internship and residency in Medicine at Johns Hopkins Hospital. Robertson was a postdoctoral fellow in Clinical Pharmacology at Vanderbilt for two years before accepting a position as assistant chief of Service in Medicine and instructor in Medicine at Johns Hopkins in 1977. In 1978, Robertson returned to Vanderbilt as assistant professor of Medicine and Pharmacology, became an associate professor in 1982, then rose to professor in 1986. He spent one year as a visiting professor in the Department of Molecular Endocrinology at National, then served as a visiting professor in the Department of Anatomy and Embryology at University College in London. In 1993, Robertson became director of the Medical Scientist Training Program at Vanderbilt University and also took the position of director of the Division of Movement Disorders in the Department of Neurology, which he held until 2000. Along with his current roles as professor of Medicine and Pharmacology and professor of Neurology, Robertson is currently the Elton Yates Professor of Autonomic Disorders, director of the General Clinical Research Center and director of the Center for Space Physiology and Medicine for Vanderbilt University. Robertson currently serves on the Board of Advisors for the World Life Foundation, the NASA Microgravity Human Research Committee, the Merck Advisory Board, and the editorial boards of American Journal of Medicine, Autonomic Neuroscience and Clinical Autnomic Research. He is also associate editor for the Journal of Pharmacology and Experimental Therapeutics. Dr. Williams' group's first major goal is the identification of the genetic underpinnings of endocrine factors related to cardiovascular (CV) risk in hypertension and diabetes with the ultimate goal of using genetic markers to develop individualized, personal treatment programs for patients with these diseases. His is a translational research group with interdisciplinary focus in humans and at the bench. The group's major focus in human studies is on careful phenotyping of patients with hypertension and diabetes relative to cardiovascular risk factors. The research focuses on evaluating hormones that can modify vascular contractility and/or salt handling. The major current thrusts are the renin-angiotensin-aldosterone system (RAAS), kallikrein, cortisol, adducin, the beta-2 adrenergic receptor and ion transport systems. The second major goal is to determine the role of aldosterone in producing CV disease at molecular, cellular, organ, whole animal and clinical levels. Recent studies suggest that aldosterone has a wide range of effects including inducing microvascular ischemia, thrombosis, fibrosis, and inflammatory responses many of them potentially mediated by aldosterone's interaction with caveolins and two recently discovered proteins---striatin and lysine specific demethylase 1 (LSD1). Techniques employed include whole animal physiological studies using normal animals, those made hypertensive and those genetically modified (e.g. knock-outs and transgenics). Molecular and cellular techniques include gene arrays using chip technology, proteomics, confocal microscopy, electrophysiology and in situ hybridization. Finally, the group has just begin the first proof of concept clinical trial for using genetic information to provide personalized medicine.
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