Clinical Proteomics 2015

Clinical Proteomics 2015 : Methods and Protocols

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This second edition expands upon the previous edition with current, detailed developments in the field and brings together a multi-disciplinary team of leading researchers to provide their latest protocols for clinical proteomics analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and Practical, Clinical Proteomics: Methods and Protocols, Second Edition presents approaches that will serve as a reliable guide to researchers, including clinicians, chemists, molecular biologists, bioinformaticians and computational, biologists, and investigators working on biomarker development.show more

Product details

  • Paperback | 278 pages
  • 178 x 254 x 15.75mm | 559g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • Revised
  • 2nd Revised edition
  • 12 black & white illustrations, 28 colour illustrations, 13 black & white tables, biography
  • 149394729X
  • 9781493947294
  • 1,247,500

Back cover copy

This second edition expands upon the previous edition with current, detailed developments in the field and brings together a multi-disciplinary team of leading researchers to provide their latest protocols for clinical proteomics analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and Practical, Clinical Proteomics: Methods and Protocols, Second Edition presents approaches that will serve as a reliable guide to researchers, including clinicians, chemists, molecular biologists, bioinformaticians and computational, biologists, and investigators working on biomarker development.show more

Table of contents

Part I : Sample Collection 1. Biological Sample Collection For Clinical Proteomics - Existing SOPs Vasiliki Lygirou, Manousos Makridakis, and Antonia Vlahou 2. Targeting The Proteome Of Cellular Fractions: Focus on Secretome Agnieszka Latosinska, Maria Frantzi, William Mullen, Antonia Vlahou and Manousos Makridakis 3. Preparation Of Urinary Exosomes: Methodological Issues For Clinical Proteomics Marina Pitto, Samuele Corbetta, and Francesca Raimondo 4. Sample Treatment Methods Involving Combinatorial Peptide Ligand Libraries For Improved Proteomes Analyses Pier Giorgio Righetti and Egisto Boschetti 5. Glycoprotein Enrichment Method Using A Selective Magnetic Nano-Probe Platform (MNP) Functionalized With Lectins Marta Cova, Rui Oliveira-Silva, Jose Alexandre Ferreira, Rita Ferreira, Francisco Amado, Ana Luisa Daniel-Da-Silva, and Rui Vitorino Part II: Technologies For Discovery and Validation 6. The Latest Advancements In Proteomic Two-Dimensional Gel Electrophoresis Analysis Applied To Biological Samples Laura Santucci, Maurizio Bruschi, Gian Marco Ghiggeri, and Giovanni Candiano 7. 2DE Maps In The Discovery Of Human Autoimmune Kidney Diseases: The Case of Membranous Glomerulonephritis Maurizio Bruschi, Laura Santucci, Gian Marco Ghiggeri, and Giovanni Candiano 8. MALDI-Imaging Mass Spectrometry on Tissues Veronica Mainini, Maciej Lalowski, Athanasios Gotsopoulos, Vasiliki Bitsika, Marc Baumann, and Fulvio Magni 9. Laser Capture Microdissection Of Fluorescently Labeled Amyloid Plaques From Alzheimer's Disease Brain Tissue For Mass Spectrometric Analysis Diana A.T. Nijholt, Christoph Stingl, and Theo M. Luider 10. Urine Sample Preparation And Fractionation For Global Proteome Profiling By LC-MS Magali Court, Jerome Garin , and Christophe D. Masselon 11. Methods In Capillary Electrophoresis Coupled To Mass Spectrometry For The Identification Of Clinical Proteomic/Peptidomic Biomarkers In Biofluids Angelique Stalmach, Holger Husi, Khedidja Mosbahi, Amaya Albalat, William Mullen, and Harald Mischak 12. Quantification Of Proteins In Urine Samples Using Targeted Mass Spectrometry Methods Nina Khristenko and Bruno Domon Part III: Extracting Biological Relevant Biomarkers and Proceeding With Implementation 13. Statistical Issues In The Design And Planning Of Proteomic Profiling Experiments David A. Cairns 14. Integrating Proteomics Profiling Data Sets - A Network Perspective Akshay Bhat, Mohammed Dakna, and Harald Mischak 15. The European Medicines Agency Experience With Biomarker Qualification Efthymios Manolis, Armin Koch, Dieter Deforce, and Spiros Vamvakasshow more