Clinical Pharmacokinetics

Clinical Pharmacokinetics

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In the complex field of pharmacokinetics, one reference guide has an identity all its own. Clinical Pharmacokinetics, the classic quick reference, comes from a distinctive voice in the field: Dr. John E. Murphy, a long-trusted source offering a straightforward, accessible approach. Now, the fully updated fifth edition brings to experienced practitioners, new practitioners, residents, and students alike the pharmacokinetic information they need most: Content organized for fast reference to specific drugs; Latest on dosing in obese and overweight patients; Dosing considerations for neonatal, pediatric and geriatric patients; A look at protein binding and its implications; Population values for a variety of drugs to initiate dosing; Drug dosing in renal disease and creatinine clearance estimation People are different. So is the 5th edition of Clinical Pharmacokinetics. This popular resource is designed as a clinical reference offering the key principles in pharmacokinetics and their applications in drug more

Product details

  • Paperback | 434 pages
  • 177.8 x 251.46 x 22.86mm | 680.39g
  • American Society of Health-System Pharmacists
  • Bethesda, United States
  • English
  • Revised
  • 5th Revised edition
  • 1585282545
  • 9781585282548
  • 911,223

Review quote

Clinical Pharmacokinetics, 5th Editionedited by John E. Murphy.The Pharmaceutical Journal; 2012; March 6th; Volume 288; Page 311Laurence A. Goldberg is a pharmaceutical consultant from Bury, Lancashire Genes are only part of the storyThis book has been written to help practitioners predict drug doses to achieve target drug concentrations from doses administered to patients. Important chapters on rational use of drug concentration measurements, dosing in overweight and obese patients, dosing considerations for a wider variety of drugs used in neonatal, paediatric and geriatric patients, drug dosing in renal disease and creatinine clearance estimation complete this fifth edition. It offers information for medicines that require an understanding of individual patients probable or actual drug concentrations to achieve medication effectiveness and safety.The authors have taken advantage of advances in knowledge to update the chapters. In many cases, more judicious monitoring of drug concentrations is suggested compared with the earlier editions. In some cases, the dosing approaches are radically different and, in others, new prediction approaches are available that have been tested in larger numbers of patients. Many chapters have been updated to take into account emerging pharmacogenetics knowledge.Typically, each chapter includes the usual dose range, the bioavailability of the dose forms, general pharmacokinetic information (absorption, distribution, elimination, metabolism, protein binding), clearance, volume of distribution, half-life and time to steady state, therapeutic range, dosing strategies, sampling times, pharmacodynamic monitoring, drug-drug interactions, pharmacodynamic interactions, drug-disease interactions and references.This book is an excellent reference source offering practitioners the key principles in pharmacokinetics and the application of these principles in drug therapy. Since the tables now comprise international and traditional units for drugs and laboratory tests, the book can be used across the world. All workers in this area of practice should have access to this fine work.--Laurence A. Goldberg"The Pharmaceutical Journal" (03/06/2012)"show more

About John E. Murphy

John E. Murphy, PharmD, is Professor of Pharmacy Practice and Science and Associate Dean for Academic and Professional Affairs at the College of Pharmacy, and Professor of Clinical, Family and Community Medicine at the College of Medicine, the University of Arizona in Tucson. He is also an Honorary Professor at the University of Otago School of Pharmacy in Dunedin, New Zealand. Dr. Murphy served as Head of the Department of Pharmacy Practice and Science at the College of Pharmacy from 1991 to 2006. John received BS in pharmacy and PharmD degrees from the University of Florida in Gainesville, where he was a recipient of the Distinguished Pharmacy Alumnus Award in 1998. He spent 12 years on the faculty at Mercer University Southern School of Pharmacy in Atlanta, where he also served as Director of Pharmacokinetic Services at a 500 bed medical center.Long active in pharmacy organizations, Dr. Murphy was president of the American College of Clinical Pharmacy (ACCP) in 2008-2009. He served as president (1997-1998) and member of the Board of Directors (1994-1999) of the American Society of Health-System Pharmacists (ASHP) and as president of the Georgia Society of Hospital Pharmacists. John has been awarded fellow status in three organizations ACCP, the American College of Clinical Pharmacology, and ASHP.Dr. Murphy has published over 200 papers, 90 abstracts, and four editions of Clinical Pharmacokinetics. John was Co-Director from 2000-2005 of the Arizona Clinical Research Training Program (AzCRTP), an NIH K30 Clinical Research Curriculum Award. His research interests include preventing drug-drug interactions, pharmacy education, and clinical pharmacokinetics. Among various professional and teaching awards received over the years, John was honored with the Award for Sustained Contributions to the Literature of Pharmacy Practice from the American Society of Health-System Pharmacists Foundation in 2003. "show more

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