Clinical Manual of Drug Interaction Principles for Medical Practice

Clinical Manual of Drug Interaction Principles for Medical Practice

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Description

Drug interactions have become a significant iatrogenic complication, with as many as 5% of hospitalizations and 7,000 deaths annually attributable to drug-drug interactions in the United States. There are several reasons these numbers have increased. First, many new medications have been brought to market in recent years. Second, advances in medical care have resulted in increased longevity and more elderly patients than ever before -- patients who are more likely to be following polypharmacy regimens. Population patterns in the U.S. have amplified this trend, with aging baby boomers swelling the patient pool and demanding treatment with medications advertised on television and in print. Fortunately, drug interactions can be prevented with access to current, comprehensive, reliable information, and the Clinical Manual of Drug Interaction Principles for Medical Practice provides just that in a user-friendly format psychiatry clinicians (including residents and nurses) and forensics experts will find indispensable. With this new edition, the book has evolved from "Concise Guide" to "Clinical Manual" and offers the expanded coverage and features healthcare providers need to keep up with this critical field. The book is well organized, with major sections on metabolism; cytochrome P450 enzymes; drug interactions by medical specialty; and practical matters, such as the medicolegal implications of drug-drug interactions and how to retrieve and review the literature. In the section on P450 enzymes, each chapter addresses what the individual enzyme does and where, its polymorphisms, and drugs that inhibit or induce activity. Each chapter also includes extensive references and study cases to help the reader understand and contextualize the information. A number of additional features enhance the book's scope and utility:  The book boasts the very latest information in the area of drug metabolism, transport, and interaction. The chapter on P-glycoprotein (a drug transporter) was expanded from the last edition to include a broader array of transport mechanisms. The highest ethical standard was adhered to in the development of this volume, which was not supported in any way by pharmaceutical makers or distributors. All eight contributors to this excellent resource are experts in the fields they have addressed, and clinicians can trust that the information contained in the Manual reflects the very latest research. This exceptionally practical manual is essential to maintaining the highest standard of care.show more

Product details

  • Paperback | 608 pages
  • 139.7 x 208.28 x 27.94mm | 657.71g
  • American Psychiatric Association Publishing
  • VA, United States
  • English
  • 9 Line drawings, unspecified; 79 Tables, unspecified
  • 1585622966
  • 9781585622962
  • 1,605,944

Review quote

"As a resident physician in a combined internal medicine/psychiatry residency program, I found this book extremely helpful. It serves as a great source when caring for patients with multiple medical problems coupled with mental illness.The large amount of information in this book justifies its change from a concise guide to a clinical manual."-- "Doddy Enterprises", "May 15, 2009" "The wrong mixture of over the counter drugs can be fetal, and doctors and pharmacists must be aware of these lethal combos. "Clinical Manual of Drug Interaction Principles for Medical Practice" is a scholarly work discussing this very real possibility that can be prevented with the right research and foresight. With the hundreds upon hundreds of new drugs entering the market every year, the research into this subject is now invaluable, as it could save thousands of lives. Filled with complete and comprehensive and up to date research on drug interaction, "Clinical Manual of Drug Interaction Principles" is strongly recommended for community and college library medicine collections."-- "the Midwest book review", "February 2009"show more

Flap copy

As every healthcare provider knows, drug-drug interactions are as prevalent as they are preventable. The Clinical Manual of Drug Interaction Principles for Medical Practice is an exceptionally practical, thoroughly up-to-date resource to help psychiatric clinicians (including residents and nurses) understand and avoid potentially dangerous interactions and provide the highest standard of patient care. Many new medications have entered the market in recent years and knowledge of pharmacokinetics and pharmacogenetics has grown significantly. From earlier versions in concise guide format, the authors have evolved this new and enlarged manual offering the expanded coverage and features that clinicians need to keep up with this critical field. Major sections cover metabolism (with new, expanded coverage of transporters); cytochrome P450 enzymes; up-to-date coverage of drug interactions by medical specialty; and practical matters, such as the medicolegal implications of drug-drug interactions and how to retrieve and review the literature. Each chapter includes extensive references and study cases to help the reader understand and contextualize the information. A summary table of drugs by specialty and their metabolic sites provides ready reference. The book's comprehensive coverage reflects the very latest research, and its user-friendly format will make it indispensable to anyone engaged in direct patient care.show more

About Gary H. Wynn

Gary H. Wynn, M.D., is Staff Psychiatrist at the Walter Reed Army Medical Center, in Washington, D.C., and Assistant Professor, Uniformed Services University School of Medicine in Bethesda, Maryland.Jessica R. Oesterheld, M.D., is Acting Director of the Spurwink Department of Psychiatry, at the Maine Medical Center, and Clinical Associate Professor at the University of Vermont College of Medicine in Burlington, Vermont.Kelly L. Cozza, M.D., FAPM, FAPA, is Associate Professor at Uniformed Services University School of Medicine in Bethesda, Maryland, and Consultant in the Department of Psychiatry at Walter Reed Army Medical Center in Washington, D.C.Scott C. Armstrong, M.D., DFAPA, FAPM, is Medical Director of Tuality Center for Geriatric Psychiatry, and Associate Clinical Professor of Psychiatry at Oregon Health and Science University in Forest Grove, Oregon.show more

Table of contents

ContributorsPrefaceAcknowledgmentsPART I: Introduction and Basic Pharmacology of Metabolic Drug InteractionsChapter 1. Introduction to Drug Interactions and to This Clinical ManualChapter 2. Definitions and Phase I MetabolismChapter 3. Metabolism in Depth: Phase IIChapter 4. TransportersPART II: P450 EnzymesIntroduction to Part IIChapter 5. 2D6Chapter 6. 3A4Chapter 7. 1A2Chapter 8. 2C9Chapter 9. 2C19Chapter 10. 2E1Chapter 11. 2A6, 2B6, and 2C8PART III: Drug Interactions by Medical SpecialtyChapter 12. Gynecology: Oral Contraceptives Chapter 13. Internal MedicineChapter 14. Infectious DiseasesChapter 15. NeurologyChapter 16. OncologyChapter 17. Pain Management I: Nonnarcotic AnalgesicsChapter 18. Pain Management II: Narcotic AnalgesicsChapter 19. PsychiatryChapter 20. Transplant Surgery and Rheumatology: ImmunosuppressantsPART IV: Practical MattersChapter 21. GuidelinesChapter 22. Medicolegal Implications of Drug-Drug InteractionsChapter 23. How to Retrieve and Review the LiteratureAppendix: Tables of Drug Interaction PharmacokineticsIndexshow more

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