Clinical Application of Cytokines

Clinical Application of Cytokines : Role in Pathogenesis, Diagnosis and Therapy

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Description

The driving force for research on cytokines has always been their clinical promise. Their biological properties suggested a key role in hematopoiesis, immunity, tumor genesis, hemostasis, vascularization, repair of connective tissues and integration of the immune system with the neuroendocrine system. Animal studies showed that cytokines could be used as effective biotherapeutics with easily manageable and reversible toxicities. Clinical trials have confirmed these findings, culminating in the licensing of a number of the cytokines such as interferon alpha, interferon gamma, interleukin 2 erythropoietin, granulocyte colony stimulating factor, and granulocyte-macrophage colony stimulating factor. Many other cytokines are in clinical trials. This is the first comprehensive volume on the cytokines written primarily from a medical perspective. After presenting background information about the structure, production, assays, and systemic effects of cytokines and their receptors, it is organized around diseases and organ systems. Infectious diseases, autoimmunity, immunodeficiency states, defective hematopoiesis, allergies, injury repair, cancer, vascular and skin diseases, and neurological disorders are all covered. These chapters review the role that cytokines play in the pathogenesis, diagnosis and therapy of each disease. The authors assess both the current state of the art and the potential for future applications.show more

Product details

  • Hardback | 396 pages
  • 233.43 x 298.45 x 41.66mm | 1,705.5g
  • Oxford University Press Inc
  • New York, United States
  • English
  • 0195071298
  • 9780195071290

Table of contents

1. Cytokines and their receptors; 2. Measurement of cytokines; 3. Applications of molecular biology to discovery, production and utilization of cytokines; 4. Regulation of the acute phase response by cytokines; 5. An overview of inflammatory consequences of cytokines in infectious diseases; 6. Role of cytokines and bacterial infections; 7. Cytokines and parasitic diseases; 8. Role of cytokines in pulmonary diseases; 9. Role of cytokines in chronic granulomatous inflammation; 10. Cytokine therapy for chronic granulomatous disease: Gamma interferon; 11. Role of cytokines in viral infections; 12. Cytokines and human retroviruses; 13. Cytokine therapy for IL-2 deficiency; 14. Role of cytokines in autoimmune disease; 15. Cytokines in rheumatoid arthritis; 16. Cytokines and Type 1 diabetes; 17. Principles of cytokine biotherapy; 18. Interferon therapy of malignant and nonmalignant disease; 19. IL-2 in cancer; 20. Evaluation of Interleukin-1 as an anti-cancer agent; 21. Pathophysiological effects of tumor necrosis factor therapy on cancer patients; 22. Interleukin 4: A potential anti-tumor and anti-inflammatory agent; 23. Role of cytokines in B cell tumors; 24. Experimental cancer cachexia: A role for IL-6; 25. Effects of local cytokine therapy; 26. Monoclonal antibodies against receptors for cytokines as potential anticancer agents; 27. Role of cytokines in hematopoiesis; 28. Cytokines in the treatment of bone marrow failure syndromes; 29. Role of cytokines in bone marrow transplantation; 30. Therapeutic utility of cytokines in counteracting the bone marrow suppression of radiotherapy and chemotherapy; 31. Erythropoietin; 32. Role of Interleukin 4 and Interleukin 5 in allergic diseases; 33. Cytokines in pathophysiologic responses in skin: Mechanisms of recruitment of inflammatory infiltrates to cutaneous tissues; 34. Use of antibodies to cytokines; 35. Recombinant toxines directed to cytokine and growth factor receptors; 36. Immunosuppressive drugs acting through blockade of cytokine expression; 37. Vascular effects of cytokines and growth-regulatory molecules; 38. Modulators of endothelial cell activity in neovascularization; 39. Cytokines and coagulation; 40. Cytokine response to surgery, trauma and burns; 41. The role of cytokines in wound repair; 42. Cytokines in muscle homeostasis and disease; 43. Trauma-induced alterations of cytokine synthesis patterns: Mechanisms and modulatory interventions; 44. Cytokines and bone remodeling; 45. Cytokines and the central nervous system; 46. Role of cytokines in peripheral nervous tissuesshow more