Foreword: Shaw, B.; Preface: Cobourne, M.T.; Epidemiology of Oral Clefts 2011: An International Perspective: Mossey, P.A.; Modell, B.; Genetic and Environmental Factors in Human Cleft Lip and Palate: Vieira, A.R.; The Mouse as a Developmental Model for Cleft Lip and Palate Research: Gritli-Linde, A.; Hedgehog Signalling in Development of the Secondary Palate: Cobourne, M.T.; Green, J.B.A.; Roles of BMP Signaling Pathway in Lip and Palate Development: Parada, C.; Chai, Y.; Development of the Lip and Palate: FGF Signalling: Stanier, P.; Pauws, E.; Wnt Signaling in Lip and Palate Development: He, F.; Chen, Y.; Treatment Outcome for Children Born with Cleft Lip and Palate: Sandy, J.; Kilpatrick, N.; Ireland, A.; Surgical Correction of Cleft Lip and Palate: Jayaram, R.; Huppa, C.; Orthodontic Treatment in the Management of Cleft Lip and Palate: Cash, A.C.; Alveolar Bone Grafting: Semb, G.; Speech and Language in the Patient with Cleft Palate: Mildinhall, S.; Future Directions: Molecular Approaches Provide Insights into Palatal Clefting and Repair: Liu, K.J.