Chiral Separations by Hplc

Chiral Separations by Hplc : Applications to Pharmaceutical Compounds

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Description

Although much information exists on the differences in biological activities, potencies, toxicities, transport mechanisms and routes of metabolism off the enantiomers, the majority of pharmaceutical compounds containing an assymetric centre are still regarded as a racemic mixture. This volume dedicated to the application of chiral high performance liquid chromatography (HPLC) to stereo-chemistry in drug action, emphasizes the biochemical and analytical biochemical aspects. The editor has gathered together many international experts, incorporating contributions from the USA, Japan, Sweden, Poland, France, The Netherlands, and the UK. The first section reviews the origins of biomolecular chirality, reminding us of Pasteur's conception of dissymetry and its relevance to today's research findings, then proceeds to discuss the importance of the enantiomeric purity of drug substances and agrochemicals. The use of enzymes in stereospecific analyses is examined, as well as optical resolution by crystallization methods. Sections two and three focus on the use of HPLC in chiral separations, a technique currently experiencing a rise in popularity as a tool for the resolution of optically active compounds, as well as future developments. A final chapter presents a range of applications of HPLC chiral stationary phases.show more

Product details

  • Hardback | 968 pages
  • 174 x 246 x 38.1mm | 997.9g
  • Taylor & Francis Ltd
  • London, United Kingdom
  • English
  • 0131312367
  • 9780131312364

Table of contents

Part 1 Principles: origin of biomolecular chirality in nature; racemates - an impediment in the use of drugs and agrochemicals; enzymes in stereo-specific analysis; perspectives for pre- or post-column enzyme reactors; optical resolution by crystallization methods. Part 2 Chiral mobile phase additives: ternary complexation; formation of diastereomeric ion pairs; cyclodextrin additives. Part 3 Enantioselective HPLC separations: introduction to chromatographic resolution of enantiomers; the use of HPLC chiral stationary phases in pharmacokinetic and pharmacodynamic studies; putting a new technology to work; polymer phases; protein-bonded phases; helical polymers as chiral stationary phases for HPLC; optically-active poly(triphenylmethylmethacrylate) and poly(diphenyl-2-pyridylmethylmethacrylate); polysaccharide phases; pirkly-type and related chiral stationary phases or enantiomeric resolutions; ligand-exchange phases; the use of chiral crown ethers in liquid chromatography; novel chiral stationary phases.show more