Chemoradiation in Cancer Therapy
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Chemoradiation in Cancer Therapy

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Description

Internationally recognized experts in cancer biology and clinical research review the present status of the multimodality approach to the management of solid tumors and speculate on possible future strategies for chemoradiation therapy. The authors detail applications of combined modality therapy in lung, esophageal, breast, gastric, pancreatic, colon, and rectal cancers. They also show how radiation interacts with such chemotherapeutic agents as the platinum complexes, taxanes, and gemcitabine in the treatment of malignant gliomas, and head and neck cancer. A review of how to integrate new specific molecular targeted agents into multimodality therapy in the future.
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Product details

  • Hardback | 420 pages
  • 167.6 x 261.6 x 27.9mm | 997.91g
  • Totowa, NJ, United States
  • English
  • 2003 ed.
  • XII, 420 p.
  • 158829028X
  • 9781588290281

Back cover copy

The combination of chemotherapeutic drugs and radiation to treat solid tumors has now become a common treatment option in many clinical settings. In Chemoradiation in Cancer Therapy, internationally recognized experts in cancer biology and clinical research review the present status of these multimodality approaches to the management of solid tumors and speculate on possible future strategies for their use. As part of their comprehensive survey, the authors detail applications of combined modality therapy in lung, esophageal, breast, gastric, pancreatic, colon, and rectal cancers. They also show how radiation interacts with such chemotherapeutic agents as the platinum complexes, taxanes, and gemcitabine in the treatment of malignant gliomas, and head and neck cancer. Rounding out the presentation is a review of how to integrate new specific molecular-targeted agents into future multimodality therapy. Here the discussion centers on the antibody for the epidermal growth factor receptor (EGFR), antiangiogenesis agents, farnesyltransferase inhibitors (FTIs), gene therapies, and signaling pathway inhibitors in combination with radiotherapy, and with or without classical chemotherapeutic agents.
State-of-the-art and forward-looking, Chemoradiation in Cancer Therapy offers oncologists a thorough understanding of today's best current and future strategies available for the treatment of solid tumors by chemoradiation therapy.
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Table of contents

Part I. General/Background

Chemoradiation: Biological Principles and Perspectives
Hak Choy and Robert M. MacRae

Fluoropyrimidines as Radiation Sensitizers
Muhammad Wasif Saif and Robert B. Diasio

Part II. Mechanisms of Interaction of Specific Chemotherapeutic Agents with Radiation

The Role of Platinum Complexes in Combined Modality Therapy
Beverly A. Teicher

Taxanes in Combined Modality Therapy
Robert M. MacRae and Hak Choy

Camptothecin Radiation Sensitization
Tyvin A. Rich

The Role of Gemcitabine in Combined Modality Therapy
Jerome Landry, William Blackstock, Robert M. MacRae, Gary Yang, and Hak Choy

Part III. Clinical Applications

Chemoradiation Strategies for Patients with Malignant Gliomas
Heather A. Curry and Walter J. Curran, Jr.

Combined Modality Strategies in the Treatment of Head and Neck Cancer
Cathy Eng and Everett E. Vokes

The Role of Combined Modality Therapy for Stage III Nonsmall-Cell Lung Cancer
Roger W. Byhardt

Combined Modality Treatment of Small-Cell Lung Cancer
Julie R. Brahmer, Larry Kleinberg, and David S. Ettinger

The Role of Chemoradiation in the Management of Esophageal Cancer
Arlene Forastiere and Bapsi Chak

Combined Modality Therapy in Locally Advanced Breast Cancer
Silvia C. Formenti and Matthew Volm

Combined Modality Therapy for Gastric, Pancreatic, and Biliary Tract Carcinomas
Alexandria Phan and Jaffer A. Ajani

Chemoradiation in Therapy for Colon and Rectum Carcinoma
Jason H. Lee and Christopher G. Willett

Chemoradiotherapy in Muscle-Invasive Bladder Cancer
Bruce J. Roth

The Role of Combined Chemotherapy and Radiation Therapy in the Treatment of Gynecologic Malignancies
Patricia J. Eifel

Part IV. Specific Molecular Targeted Agents

Overview of Specific Molecular Targeted Agents for Combined Modality Therapy
Scott Saxman and Janet Dancey

Receptor Tyrosine Kinases as Therapeutic Targets in Solid Tumors
Stacy L. Moulder and Carlos L. Arteaga

Adenoviral p53 Gene Therapy Strategies in Nonsmall-Cell Lung Cancer
Stephen G. Swisher and Jack A. Roth

Tumor Microvasculature as a Therapeutic Target During Radiotherapy
Dennis E. Hallahan and Don Stacy

Cancer Drug Discovery and Development: Maximizing the Therapeutic Potential of Matrix Metalloproteinase Inhibitors for the Treatment of Cancer
Jeffrey S. Humphrey, Karen Price, Elora Gupta, Andrew Baxter, John Bird, Daryl Sonnichsen, and Joseph Naglich

The Role of Cyclooxygenase-2 Inhibitors in Combined Modality Therapy
Hong Pyo, Raymond N. DuBois, and Hak Choy

Index
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Review quote

"Chemoradiaton in Cancer Therapy offers both clinical and basic oncologists not only a bold synthesis of the rapid and complex advances in new therapeutic modalities, but also highly practical guide to today's best strategies in cancer treatment." -Neoplasma
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