Chemical Glycobiology

Chemical Glycobiology

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Although the process of understanding the biological functions of carbohydrates has developed slowly due to the lack of efficient approaches in obtaining and studying these structures, in the past two decades, remarkable advances have been made in chemical and chemoenzymatic synthesis of carbohydrates and glycoconjugates. The material presented in this volume shows how a better understanding of the structure and the function of carbohydrate-containing bacterial cell
wall has revealed that carbohydrate-containing molecules and carbohydrate-like structures are useful as carbohydrate-based anti-microbial vaccines, anti-viral drugs, anti-coagulants, anti-cancer drugs, and potential anti-cancer vaccines. In addition, the text explores the important roles that novel
glycolipids have been found to play in the immune system.

Metabolic engineering has demonstrated itself as an efficient approach to probe and manipulate biological functions of carbohydrates both in vitro and in vivo. Automated glycan analysis, carbohydrate microarrays, and novel high-throughput screening methods have hastened the analysis and the understanding of carbohydrate-containing structures. Polypeptide-based glycopolymers have been developed for the study of multivalent binding events of carbohydrates and proteins. This text presents
examples of these recent developments in using chemical techniques and tools to study glycobiology. This is an excellent reference book for upper-division undergraduate students, graduate students, and researchers who are interested in carbohydrate-related medicinal chemistry, organic chemistry, biology,
and chemical biology.
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Product details

  • Hardback | 340 pages
  • 159 x 235 x 20mm | 577g
  • New York, United States
  • English
  • New
  • 140 line illustrations
  • 0841274401
  • 9780841274402

Table of contents

Preface ; Chemical Synthetic Methods for Chemical Glycobiology ; 1. De Novo Synthesis in Carbohydrate Chemistry: From Furans to Monosaccharides and Oligosaccharides ; 2. Chemical Syntheses of Hyaluronic Acid Oligosaccharides ; 3. Synthetic Efforts in Preparations of Components of the Bacterial Cell Wall ; 4. New Glycosyl Thio-carboamino Peptides as New Tools for Glycobiology ; Chemoenzymatic Methods for Chemical Glycobiologu ; 5. Chemoenzymatic Synthesis of Sialosides and Their Applications ; 6. Convergent Chemoenzymatic Synthesis of Complex N-Glycopeptides ; Glycolipids ; 7. Synthesis of Glycolipid Antigens ; 8. Synthesis of Glycolipid Glycosphingolipids ; Glycovaccines ; 9. Clinical Outcome of Breast and Ovarian Cancer Patients Treated after High-dose Chemotherapy and Autologous Stem Cell Rescue with Theratope (STn-KLH) Cancer Vaccine: Theratope (STn-KLH) Cancer Vaccine following Autologous Transplant ; 10. Synthesis and Evaluation of Anticancer Vaccine Candidates, C-Glycoside Analogs of STn and PSA ; Tools for Chemical Glycobiology ; 11. An Automated Method for Determining Glycosylation and Site Diversity in Glycoproteins ; 12. Chemical Approaches to Glycobiology ; 13. Automated Solution-Phase Oligosaccharide Synthesis and Carbohydrate Microarrays: Development of Fluorous-Based Tools for Glycomics ; 14. Polypeptide-Based Glycopolymers for the Study of Multivalent Binding Events
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About Randall L. Halcomb

Xi Chen is Assistant Professor of Bioorganic Chemistry at the University of California, Davis. Professor Chen has received an NSF CAREER Award and a Beckman Young Investigator Award. She is an Alfred P. Sloan Research Fellow.

Randall Halcomb currently holds the title of Senior Research Scientist II in the department of Medicinal Chemistry at Gilead Sciences.

Peng George Wang is Professor and Ohio Eminent Scholar in the Departments of Biochemistry and Chemistry at the Ohio State University.
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