Central and Peripheral 5-HT3 Receptors

Central and Peripheral 5-HT3 Receptors

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This text offers an extensive overview of the present knowledge of 5-HT3 receptors in the central nervous system and the periphery with regard to their exclusive location on neurones and their pharmacological, biochemical and functional properties. Among its 12 chapters, 5 are devoted to the present and potential use of 5-HT3 ligands in the treatment of visceral dysfunctions, schizophrenia, anxiety and pain. Although these chapters have been written by specialists in the field, they are understandable by anyone interested not only in serotonin neurotransmission and neurotransmitter receptors but also in neurobiology in general. This book should also be especially helpful for physicians and medical students involved in neurology and psychiatry.
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Product details

  • Hardback | 352 pages
  • 149.86 x 228.6 x 25.4mm | 566.99g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0123223709
  • 9780123223708

Table of contents

The history of 5-HT3 receptors; 5-HT3 receptors at the periphery - physiology and pharmacology; 5-HT3 receptors in the central nervous system; autoradiographic mapping of 5-HT3 receptors; biochemical and physicochemical properties of 5-HT3 receptors; 5-HT3 receptors as cation channels; biochemical responses of 5-HT3 receptor simulation at the cellular level; the role of 5-HT3 receptors in 5-HT-DA interactions in the central nervous system - potential therapeutic value of 5-HT3 antagonists as antipsychotic drugs; present and future therapeutic applications of 5-HT3 agonists/antagonists acting on the neurovegetative system; the potential use of 5-HT3 antagonists as anxiolytics; the role of peripheral and central 5-HT3 receptors in the control of nociceptive messages; the clinical perspectives of drugs acting at 5-HT3 receptors.
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