Cellular Connectomics

Cellular Connectomics

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The field of cellular connectomics is technically challenging and highly multi-disciplinary, creating need for a connectomics methods volume suitable for both researchers and students aiming to gain familiarity with the field. Cellular Connectomics offers just that: an accessible, practical and comprehensive introduction to the fundamental principles and practices of cellular connectomics. With the bulk of the volume written by two pioneers in the field, plus 3 chapters authored by opinion leaders offering future predictions, the volume offers readers both consistent voice/uniform structure and cutting edge insights. Focusing on "cellular" connectomics with the goal of reconstructing neuronal wiring diagrams at the level of single neurons/synapses, the volume provides a conceptual overview of the goals and challenges of this methodology. * The first volume to offer a step-by-step introduction to cellular connectomics suitable for both researchers and students.* Coverage includes: tissue preparation, sectioning and imaging techniques, approaches for data reconstruction, circuit analysis, and an explanation of successful connectomic reconstructions to date.*
Offers balanced discussion what does and does not work, as well as of the current debates about whether a connectomic era is going to replace decades of functional data collection.
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Product details

  • Hardback | 300 pages
  • 190.5 x 234.95mm
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0124103952
  • 9780124103955

About Moritz Helmstaedter

Dr. Helmstaedter has pioneered large-scale circuit reconstruction using crowd-sourcing and machine learning. His laboratory spearheads large-scale crowd sourcing and online annotation approaches for connectomics, with a focus on the connectomic reconstruction of the cerebral cortex. Dr. Briggman brings specific expertise in the tissue preparation and imaging methods. He is heading one of the few laboratories in the world that are able to produce and analyze connectomic datasets.
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Table of contents

1. Why connectomics?

2. Methods for 3D Electron Microscopy

3. Tissue preparation

4. Correlative microscopy

5. Structural properties of nerve tissue and manual image analysis

6. Automated analysis of 3D EM data

7. Integrated high-throughput connectomics analysis

8. Successes in connectomics

9. Future of connectomics

10. Future vision 1

11. Future vision 2

12. Future vision 3
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