Cell Cycle Deregulation in Cancer

Cell Cycle Deregulation in Cancer

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Cancer is fundamentally a disease of abnormal cell proliferation: Cancer cells multiply when and where they should not. This proliferation entails escape from normal bounds imposed by the tissue environment, the internal biology of the cell (DNA damage, chromosomal imbalances, disorganized mitotic spindles), and the proliferative history of the cell (normal generational times). Some of the key oncogenic events in cancer directly perturb proteins that regulate progression through the cell division cycle, others alter cell cycle progression indirectly, through effects on signaling pathway that impinge on the cell cycle. This biology is fundamentally important in cancer therapy. Many of the workhorse treatments for cancer rely on killing proliferating cells. Furthermore, there is growing recognition that stem cell-transit amplifying cell hierarchies may persist or be generated during tumorigenesis, generating important functional heterogeneity in cell cycle control among tumor cells, with far-reaching scientific and clinical implications. This volume outlines major cell cycle perturbations that drive tumorigenesis and considers the prospects for using such knowledge in cancer therapy.
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Product details

  • Hardback | 206 pages
  • 155 x 235 x 17.78mm | 530g
  • New York, NY, United States
  • English
  • 2010 ed.
  • 1 Tables, black and white; 11 Illustrations, color; 8 Illustrations, black and white; VIII, 206 p. 19 illus., 11 illus. in color.
  • 1441917691
  • 9781441917690

Back cover copy

Modern studies of regulation of the cell division cycle were pioneered by Leland Hartwell, Paul Nurse, and Tim Hunt in yeast and marine invertebrates. This work identified proteins termed cyclins that fluxuate in abundance during progression through the cycle and partner with Cyclin dependent kinases (Cdks) to drive major cell cycle transitions. Much has been learned since about how these and other proteins control cell cycle progression in all eukaryotes, including man. Further research is uncovering how these controls are de-regulated in cancer, a disease of unbridled cell proliferation that is the leading cause of death in developed countries. However, there is much more to be learned, and the hard won gains are just beginning to impact cancer care. In 11 reviews by leading experts, this volume lays out the current state and directions of the field for biomedical scientists of all training levels.

The collection begins with three reviews that delineate how cells initiate the cell cycle, from growth factor stimulation to activation of key transcription programs and origins of DNA replication. The next three reviews address issues of proliferation under duress, including how derangement of mitotic checkpoints can lead to cell death or genetic instability and how recycling of intracellular molecules (autophagy) is regulated. The next three reviews address the special context of long-term proliferation--how it is regulated in stem cells, how it can erode telomeric structures on the tips of chromosomes, and how it can culminate in senescence. The last two reviews describe how cell cycle advances are beginning to touch patients, in the characterization of pre-malignant states and in cancer therapy.
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Table of contents

Starting the cell division cycle

Elena Sotillo and Xavier Grana

Escape from cellular quiescence

Jun-Yuan Ji and Nicholas J. Dyson

Interplay between Cyclin-dependent Kinases and E2F-dependent Transcription.

A. Kathleen McClendon, Jeffry L. Dean, and Erik S. Knudsen
Regulation of pre-RC assembly: A complex symphony orchestrated by CDKs

Proliferation under duress

Haomin Huang and Timothy J Yen

Mitotic checkpoint and chromosome instability in cancer

Jeremy P.H. Chow and Randy Y.C. Poon

Mitotic catastrophe

Robert D. Hontz and Maureen E. Murphy

p53, ARF and the control of autophagy

Long-term proliferation

Andrea Viale and Pier Giuseppe Pelicci

Regulation of self-renewing divisions in normal and leukaemia stem cells

Eros Lazzerini Denchi

Maintenance of Telomeres in Cancer

Peter D. Adams

The senescence secretome and its impact on tumor suppression and cancer

Applications in preventing and treating cancer

Pierre Lao-Sirieix and Rebecca C Fitzgerald

Cell cycle deregulation in pre-neoplasia: case study of Barrett's esophagus

Neil Johnson and Geoffrey I. Shapiro

Targeting cyclin dependent kinases for cancer therapy
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