Catecholamine Function in Posttraumatic Stress Disorder

Catecholamine Function in Posttraumatic Stress Disorder : Emerging Concepts

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Catecholamine Function in Posttraumatic Stress Disorder: Emerging Concepts provides clinicians and scientists alike with a comprehensive and up-to-date review of basic neurobiology and clinical science related to catecholaminergic systems in posttraumatic stress disorder (PTSD). The book begins by defining clinical and scientific terms to orient readers from diverse disciplines. It then presents a number of chapters discussing the neurobiology of central catecholaminergic systems, how these are altered by stress in animals, and what significance such basic scientific findings may have for the clinical syndrome of PTSD. It then proceeds to describe what is currently known about changes in central and peripheral catecholaminergic systems in PTSD, followed by a review of antidepressant treatment of the disorder. The book finishes with a chapter discussing methodological considerations for studies of catecholaminergic systems in humans, and a commentary regarding limitations of animal models of PTSD, adding an evaluatory dimension to the overall work. PTSD is unique in having its main etiology in stressful life experiences; however, an understanding of the cascade of biological changes set into motion by stress exposure has potential application to other stress-exacerbated mental disorders as well.show more

Product details

  • Paperback | 404 pages
  • 140 x 210 x 21.08mm | 467.2g
  • American Psychiatric Association Publishing
  • American Psychiatric Publishing
  • VA, United States
  • English
  • 1585624470
  • 9781585624478

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Catecholamine Function in Posttraumatic Stress Disorder: Emerging Concepts provides clinicians and scientists alike with a comprehensive and up-to-date review of basic neurobiology and clinical science related to catecholaminergic systems in posttraumatic stress disorder (PTSD). The book begins by defining clinical and scientific terms to orient readers from diverse disciplines. It then presents a number of chapters discussing the neurobiology of central catecholaminergic systems, how these are altered by stress in animals, and what significance such basic scientific findings may have for the clinical syndrome of PTSD. It then proceeds to describe what is currently known about changes in central and peripheral catecholaminergic systems in PTSD, followed by a review of antidepressant treatment of the disorder. The book finishes with a chapter discussing methodological considerations for studies of catecholaminergic systems in humans, and a commentary regarding limitations of animal models of PTSD, adding an evaluatory dimension to the overall work. PTSD is unique in having its main etiology in stressful life experiences; however, an understanding of the cascade of biological changes set into motion by stress exposure has potential application to other stress-exacerbated mental disorders as well.show more

About M.Michele Murburg

M. Michele Murburg, M.D., is Associate Professor in the Department of Psychiatry and Behavioral Sciences at the University of Washington; Visiting Associate Professor in the Department of Psychiatry and Behavioral Sciences at Stanford University; and Associate Director for Neurobiological Research at the National Center for Post-Traumatic Stress Disorder, Education and Clinical Research Division, VA Medical Center, in Palo Alto, California.show more

Table of contents

Contributors. Introduction to the progress in psychiatry series. Foreword. Introduction. Section I: The Role of Catecholaminergic Systems in Stress Response Syndromes. Biology of catecholaminergic systems and their relevance to PTSD. Locus coeruleus, stress, and PTSD: neurobiological and clinical parallels. Altered electrophysiology of the locus coeruleus following uncontrollable stress: relationship to anxiety and anxiolytic action. Time-dependent change following acute stress: relevance to the chronic and delayed aspects of PTSD. Stressors, the mesocorticolimbic system, and anhedonia: implications for PTSD. Neurobiological mechanisms of PTSD. Section II: Peripheral Autonomic and Catecholamine Function in PTSD. Psychophysiological studies of combat-related PTSD: an integrative review. Basal sympathoadrenal function in patients with PTSD and depression. Stress-induced alterations in plasma catecholamines and sympathetic nervous system function in PTSD. Relationship between catecholamine excretion and PTSD symptoms in Vietnam combat veterans and Holocaust survivors. Plasma norepinephrine and MHPG responses to exercise stress in PTSD. Neurobiological sequelae of childhood trauma: PTSD in children. Peripheral adrenergic receptors in PTSD. Section III: Central Catecholamine Function in PTSD. Neurobiology of startle response abnormalities in PTSD. Use of tricyclics and monoamine oxidase inhibitors in the treatment of PTSD: a quantitative review. Section IV: Methodological Issues. Assessment of sympathetic nervous system function in PTSD: a critique of methodology. Comment: determining the applicability of animal models of stress to the study of PTSD. Afterword. Index.show more