List of Contributors. Preface. 1. Cardiology Approaching the Year 2000. A Clinician's Look at Molecular Cardiology; H.J. Wellens. Part One: Cardiovascular Specific Gene Expression. 2. The Transcriptional Building Blocks of the Heart; D. Franco, et al. 3. A Cardiac-Specific Troponin I Promoter. Distinctive Patterns of Regulation in Cultured Fetal Cardiomyocytes, Adult Heart and Transgenic Mice; S. Schiaffino, et al. 4. Mice Deficient in Muscle LIM Protein (MLP) Reveal a Pathway to Dilated Cardiomyopathy and Heart Failure; P. Caroni. 5. Regulation of Endothelial Cell Specific Receptor Tyrosine Kinase Gene Expression during Development and Disease; T.M. Schlaeger. 6. Smoothelins: One Gene, Two Proteins, Three Muscle Cell Types ... so Far; G.J.J.M. van Eys, et al. Part Two: Transcription Regulation. 7. Regionalization of Transcriptional Potential in the Myocardium: `Cardiosensor' Transgenic Mice; R.G. Kelly, et al. 8. Human Troponin Genes: Transcriptional Regulation and Chromosomal Organization; P.J. Barton, et al.9. Retinoid Signaling: Insight from Genetically Engineered Mice; P. Ruiz-Lozano, K.R. Chien. 10. Ventricular Expression of the Atrial Regulatory Myosin Light Chain Gene; P.A. Doevendans, et al. 11. Expression of Rat Gap Junction Protein Connexin 40 in the Heart; W.A. Groenewegen. Part Three: Ion Channels and Gap Junction. 12. Sympathetic Regulation of Cardiac Delayed Rectification: Relationship to Cardiac Arrhythmias; R.S. Kass. 13. The Sarco(endo)plasmic Reticulum Ca2+ Pumps in the Cardiovascular System; A.-M. Lompre, et al. 14. Potassium Channels; Genes, Proteins, and Patients; C. Alshinawi, A.A.M. Wilde. 15. Expression of Cx43 in Cardiac and Aortic Muscle Cells of Hypertensive Rats; J.-A. Haefliger, P. Meda. 16. Genetic Engineering and Cardiac Ion Channels; A.A. Grace, et al. Part Four: Intracellular Signaling. 17. Receptor Tyrosine Kinase Signaling in Vasculogenesis and Angiogenesis; T.I. Koblizek, et al. 18. Molecular Analysis of Vascular Development and Disorders; P. Carmeliet, D. Collen. 19. Crosstalk Between the Estrogen Receptor and the Insulin-like Growth Factor (IGF-1) Receptor. Implications for Cardiac Disease; Ch. Grohe 20. Expression of Basic Helix-Loop-Helix Proteins and Smooth Muscle Phenotype in the Adult Rat Aorta; P.R. Kemp, J.C. Metcalfe. 21. Expression of the IGF System in Acute and Chronic Ischemia; E. Deindl, et al. 22. Long-Chain Fatty Acids and Signal Transduction in the Cardiac Muscle Cell; M. van Bilsen, et al. Part Five: DNA Transfer. 23. Reduction of Kidney Renin Expression by Ribozymes; M.G.F. Sharp, et al. 24. Receptor-Dependent Cell Specific Delivery of Antisense Oligonucleotides; E.A.L. Biessen, T.J.C. van Berkel. 25. Tissue-Specific Gene Delivery by Recombinant Adenoviruses Containing Cardiac-Specific Promoters; W.-M. Franz, et al. 26. Catheter-Mediated Delivery of Recombinant Adenovirus to the Vessel Wall to Inhibit Restenosis; O. Varenne, et al. Index.