Cardiovascular Biology: v. 1

Cardiovascular Biology: v. 1 : Endothelial Cell in Health and Hypertension

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This volume has a focus on Vascular Endothelium, NO and Hypertension and is a continuum of the volumes on Mechanobiology of Cartilage and Chondrocyte. Indeed, vascular endothelial plays a significant role in regulating blood flow, and endothelial cells (EC) have highly active metabolic functions. They generate vasoactive mediators like prostacyclin, nitric oxide (NO) and endothelin (ET-1). Endothelial cells also synthesize various proteins like Von Willebrand's factor, growth factors and tissue plasminogen activators. They have also enzymes that inactivate bradykinin and convert angiotensin I into angiotension II (a vasopressor agent). In other respects, it is now well-known that mechanical forces and stretch can modulate EC functions by activating mechano-sensors, signaling pathways, genes and protein expressions. This mechanical approach leads to a better knowledge of vascular remodeling observed in many pathologies. These different aspects are all covered in this more

Product details

  • Hardback | 220 pages
  • 195.58 x 266.7 x 20.32mm | 703.06g
  • IOS Press
  • IOS Press,US
  • Amsterdam, United States
  • English
  • Illustrated
  • Illustrated edition
  • 1586037757
  • 9781586037758