Cancer Gene Therapy
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Cancer Gene Therapy

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Description

A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.
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Product details

  • Paperback | 490 pages
  • 189.99 x 254 x 28.96mm | 948g
  • Totowa, NJ, United States
  • English
  • Softcover reprint of hardcover 1st ed. 2005
  • XII, 490 p.
  • 1617374253
  • 9781617374258

Back cover copy

Today a new generation of powerful cancer therapeutics targeted against the molecular pathways that produce malignant phenotypes is rapidly emerging. In Cancer Gene Therapy, leading basic and clinical cancer oncologists provide a complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. In their discussions, the authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.
Authoritative and wide ranging, Cancer Gene Therapy offers a comprehensive survey of the molecular basis of cancer gene therapy and demonstrates its enormous potential to take a place in the clinic alongside the current generation of anticancer therapeutics.
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Table of contents

Cancer Gene Therapy: Historical Perspective
Malcolm K. Brenner

The Genetic Basis of Cancer
Akseli Hemminki and Kari Hemminki

Tumor Suppressor Gene Replacement for Cancer
Jack A. Roth and Susan F. Grammer

Antisense Technology
Ruiwen Zhang and Hui Wang

Cancer Therapeutic Applications of Ribozymes and RNAi
Lisa Scherer and John J. Rossi.

Fusogeneic Membrane Glycoproteins for Cancer Gene Therapy: A Better Class of Killer
Andrew Bateman, Vy Phan, Alan Melcher, Emmanouela Linardakis, Kevin Harrington, and Richard Vile

Suicide Gene Therapy
Caroline J. Springer and Ion Niculescu-Duvaz

Molecular Chemotherapy Approaches
Daniel H. Palmer and David J. Kerr

Genetic Immunotherapy Approaches
Denise R. Shaw and Albert F. LoBuglio

Immunotherapy of Cancer By Dendritic Cell-Targeted Gene Transfer
Tanja D. de Gruijl, Herbert M. Pinedo, and Rik J. Scheper.

Dendritic Cells
Weiping Zou, Shuang Wei, and Tyler J. Curiel

Polynucleotide Immunization for Cancer Therapy
Theresa V. Strong

Development of Oncolytic Replication-Competent Herpes Simplex Virus Vectors: The G207 Paradigm
Tomoki Todo and Samuel D. Rabkin

Development of Oncolytic Adenoviruses: From the Lab Bench to the Bedside
John A. Howe, Robert Ralston, and Murali Ramachandra

Conditionally Replicating Adenoviruses for Cancer Treatment
Ramon Alemany

Reovirus as an Oncolytic Agent
Megan K. Patrick, Kara L. Norman, and Patrick W. K. Lee

Antiangiogenic Gene Therapy of Cancer
Steve Gyorffy, Jack Gauldie, A. Keith Stewart, and Xiao-Yan Wen

Proapoptotic Strategy in Cancer Gene Therapy
David H. Holman, Marc L. Hyer, Ahmed El-Zawahry, Gina M. Keller, and James S. Norris

Antimetastasis
Duen-Hwa Yan, Kung-Ming Rau, and Mien-Chie Hung

Antimetastatic Gene Therapy: Prostate Cancer Theory to Therapy
Thomas A. Gardner, Juan Antonio Jimenez, Leland W. K. Chung, and Chinghai Kao

Drug Resistance Gene Transfer as an Antitumor Strategy
Colin L. Sweeney and R. Scott McIvor

Chemosensitization
Per Eystein Lonning

Radiosensitization by Gene Therapy
Steven J. Chmura, Michael Garofalo, and Ralph R. Weichselbaum

Nonviral Vector Systems for Cancer Gene Therapy
Greg F. Walker and Ernst Wagner

Viral Vectors for Cancer Gene Therapy
Joanne T. Douglas and David T. Curiel

Bacterial Systems for Tumor-Specific Gene Therapy
J. Martin Brown, Shie-Chau Liu, Jan Theys, and Philippe Lambin

Molecular Imaging of Cancer Gene Therapy
Harvey R. Herschman

Cancer-Related Gene Therapy Clinical Trials
Robert J. Korst and Ronald G. Crystal

Regulatory Aspects in the Development of Gene Therapies
Rosemarie Aurigemma, Joseph E. Tomaszewski, Sheryl Ruppel, Stephen Creekmore, and Edward A. Sausville

Index
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Review quote

"...represents an outstanding work, which should not be missed in all laboratories dealing with cancer gene therapy." - Neoplasma
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