Cancer Cytogenetics

Cancer Cytogenetics : Methods and Protocols

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Description

This is a collection of key cytogenetic and FISH techniques used by modern clinical laboratories in the genetic analysis of human malignancies. The book's practical advice and methods are suitable for use at every level of expertise, including fully established laboratories, but with a sympathetic bias towards anyone considering setting up a new cytogenetics service. Here the reader will find not only elementary tutorials on the fundamentals of human karyotypes and chromosome analysis, but also detailed discussions on how laboratories may optimally upgrade their repertoire of capabilities to include such newer complementary techniques as CGH, FISH, and M-FISH.show more

Product details

  • Hardback | 296 pages
  • 157.5 x 233.7 x 20.3mm | 680.4g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • 56 black & white illustrations
  • 1588290808
  • 9781588290809

Back cover copy

Cytogenetic studies of malignancy have become an essential tool in the clinical management of cancer patients, but they are not uniformly utilized, even in well-developed countries. In Cancer Cytogenetics: Methods and Protocols, experienced cytogeneticists describe in step-by-step detail the key cytogenetic and FISH techniques used by modern clinical laboratories in the genetic analysis of human malignancies, as well as explain how best to interpret the results. The book's practical advice and methods are suitable for use at every level of expertise, including fully established laboratories, but with a sympathetic bias toward anyone considering setting up a new cytogenetics service. Here the reader will find not only elementary tutorials on the fundamentals of human karyotypes and chromosome analysis, but also detailed discussions on how laboratories may optimally upgrade their repertoire of available capabilities to include such newer complementary techniques as CGH, FISH, and M-FISH. Each protocol contains many novel ideas and time-saving techniques, expert commentary, tricks of the trade, alternative approaches, and suggestions that will help yield the results that clinicians want. Eminently practical for every stage of diagnostic service, Cancer Cytogenetics: Methods and Protocols offers hospital and other pathology laboratories a user-friendly collection of both standard and advanced techniques, all carefully designed to improve the diagnosis and clinical management of cancer patients today.show more

Review quote

"Eminently practical for every stage of diagnostic service, this book offers laboratories a user-friendly collection of standard and advanced techniques, carefully designed to improve diagnosis and clinical management of cancer patients." - Clinical Laboratory International "...an immensely useful book for anyone working in the field of cytogenetics. The author has filled this volume with the sort of detail that enables ready translation of methods into practice and provides clear explanations of individual steps within procedures..." - Cancer Forumshow more

Table of contents

Introduction John Swansbury Cytogenetic Studies in Hematologic Malignancies: An Overview John Swansbury The Myeloid Disorders: Background John Swansbury Cytogenetic Techniques for Myeloid Disorders John Swansbury Acute Lymphoblastic Leukemia: Background John Swansbury Conventional Cytogenetic Techniques in the Diagnosis of Childhood Acute Lymphoblastic Leukemia Susana C. Raimondi and Susan Mathew Chromosome Preparations from Bone Marrow in Acute Lymphoblastic Leukemia: Cytogenetic Techniques Ann Watmore Lymphoid Disorders Other than Common Acute Lymphoblastic Leukemia: Background John Swansbury Other Lymphoid Malignancies: Cytogenetic Techniques John Swansbury Cytogenetic and Genetic Studies in Solid Tumors: Background John Swansbury Human Solid Tumors: Cytogenetic Techniques Pietro Polito, Paola Dal Cin, Maria Debiec-Rychter, and Anne Hagemeijer Analysis and Interpretation of Cytogenetic Findings in Malignancies John Swansbury Cytogenetic Studies Using FISH: Background Toon Min and John Swansbury FISH Techniques Toon Min FISH, CGH, and SKY in the Diagnosis of Childhood Acute Lymphoblastic Leukemia Susan Mathew and Susana C. Raimondi Solving Problems in Multiplex FISH Jon C. Strefford Some Difficult Choices in Cytogenetics John Swansbury Introduction to the Analysis of the Human G-Banded Karyotype John Swansbury Index About the Authorsshow more