Cancer Biology

Cancer Biology

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Provides a clear, concise and authoritative introduction to the biological principles that underlie the causes and treatment of cancer. The authors draw on their extensive teaching experience to guide students through this complex subject, and knit together the diverse areas encompassed in the study of cancer. This third edition is updated to include areas of recent research which excite student more

Product details

  • Paperback | 312 pages
  • 190 x 244 x 24mm | 621.43g
  • Pearson Education (US)
  • Prentice Hall
  • Upper Saddle River, United States
  • English
  • 3rd edition
  • 0131294547
  • 9780131294547
  • 782,941

Back cover copy

This third edition of "Cancer Biology" provides a clear and concise update of this well respected introductory texton the biological principles of the causes and treatment of cancer. The bookhas been updated to include areas of recent research to give a more student friendly approach. Several chapters have been revsied and expanded where appropriate, but it's overall comprehensive coverage of the subject has been maintained throughout. Key features concise introduction to the subject comprehensive up-to-date coverage of key topics in cancer biology chapters have been updated to include any new developments, where appropriate illustrations have been amended toreflect current data references have been moved to the end of each chapter the glossary has been expanded "Cancer Biology" is an essential text for students of cell biology, biochemistry, molecular biology, genetics and biomedical sciences. It will also be valuable to postgraduate students moving into cancer research. Roger J. King is Honorary Professor in Cellular Oncology at Surrey University, UK. He was formerly Chairman of the International Society for Hormones and Cancer, Head of the Hormone Biochemistry Department at the Imperial Cancer Research Fund Laboratories and a consultant to the World Health Organisation. Mike Robins was formally Senior Lecturer in Physiology at Kings College, London. "show more

Table of contents

Detailed contents PrefacePreface to the second editionPreface to the first editionAcknowledgementsBasic science, terminology and abbreviations 1. What is cancer?IntroductionCarcinogenesis requires several cellular changesLifestyle and family influences on cancerChanges continue to accumulate after cancer formationCancers are most common in epithelial cellsCancer results from uncontrolled growthCancer genesInvasion and metastasisSome cancers are curablePrevention, screening and treatmentFurther readingWebsites 2. Natural history: the life of a cancerIntroductionClonal origins of cancerExperimental biologyBox2.1: Special mice used in cancer researchClinical dataLinking laboratory and clinic 3. Pathology: defining a neoplasmIntroductionBox3.1: Classifying cancersHistopathologyCytologyImmunohistochemistryMolecular techniquesFurther reading 4. Epidemiology: identifying causes for human cancersIntroductionDescriptive epidemiologyBox4.1: Epidemiological methods and terminologyAnalytical epidemiologyCriteria required to establish causalityBiomarkersMolecular epidemiologyFactors that influence human carcinogenesisCancer preventionFurther reading 5. Oncogenes, tumour suppressor genes and virusesIntroductionBox5.1: Molecular terms relevant to genes and their regulationOncogenesTumour suppressor genesOncogenes and tumour suppressors cooperateFurther reading 6. Chemical and radiation carcinogenesisIntroductionChemical carcinogenesisRadiation carcinogenesisConsequences of DNA damagePredicting the type of carcinogen by mutational spectrum analysisFurther reading 7. Mutations, DNA repair and genetic instabilityIntroductionMutationsGenetic instabilityTypes of DNA damageClinical evidence that links DNA repair and carcinogenesisRepair mechanismsCoordination of DNA repair, proliferation and apoptosisFurther reading 8. Familial cancersIntroductionBox8.1: Chromosome nomenclature and structureStrong familial linkWeaker familial linkConnection with sporadic cancersFurther reading 9. Growth: a balance of cell proliferation, death and differentiationIntroductionNormal proliferation and its regulationBox9.1: BNA synthesis and telomere lengthCancer cellsSenescence, cell mortality and telomeraseCell deathApoptosis and cancerIntegration of proliferation, apoptosis and DNA repairDifferentiationFurther reading 10. Responding to the environment: growth regulation and signal transductionGeneral featuresGrowth factorsGrowth factor receptorsGrowth factors: from membrane to nucleusNuclear events stimulated by growth factorsCell adhesion moleculesBox10.1: How a cell interacts with its environmentHydrophobic growth regulatory moleculesCross-talk between signalling pathwaysFurther reading 11. Invasion and metastasisIntroductionGeneral featuresEscape from local control and invasionIntravasationAngiogenesisGene changes involved in metastasisFurther reading 12. Principles of cancer treatmentIntroductionPrinciples behind the treatment of cancerChemotherapyHormone therapyImmunotherapy/biological response modifier therapyPhotodynamic therapyNew forms of treatmentFurther reading 13. Approaches to cancer preventionIntroductionBreast cancer, tamoxifen and anastrozoleEndometrial/ovarian cancer and the contraceptive pillColoncancer and non-steroidal anti-inflammatory drugsDietFurther reading Appendix: Features of selected cancersGlossaryIndexshow more

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