Cancer Biology

Cancer Biology

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Description

Provides a clear, concise and authoritative introduction to the biological principles that underlie the causes and treatment of cancer. The authors draw on their extensive teaching experience to guide students through this complex subject, and knit together the diverse areas encompassed in the study of cancer. This third edition is updated to include areas of recent research which excite student interest.
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Product details

  • Paperback | 312 pages
  • 190 x 244 x 24mm | 621.43g
  • Prentice Hall
  • Upper Saddle River, United States
  • English
  • 3rd edition
  • 0131294547
  • 9780131294547
  • 845,853

Back cover copy

This third edition of "Cancer Biology" provides a clear and concise update of this well respected introductory texton the biological principles of the causes and treatment of cancer. The bookhas been updated to include areas of recent research to give a more student friendly approach. Several chapters have been revsied and expanded where appropriate, but it's overall comprehensive coverage of the subject has been maintained throughout. Key features concise introduction to the subject comprehensive up-to-date coverage of key topics in cancer biology chapters have been updated to include any new developments, where appropriate illustrations have been amended toreflect current data references have been moved to the end of each chapter the glossary has been expanded "Cancer Biology" is an essential text for students of cell biology, biochemistry, molecular biology, genetics and biomedical sciences. It will also be valuable to postgraduate students moving into cancer research.
Roger J. King is Honorary Professor in Cellular Oncology at Surrey University, UK. He was formerly Chairman of the International Society for Hormones and Cancer, Head of the Hormone Biochemistry Department at the Imperial Cancer Research Fund Laboratories and a consultant to the World Health Organisation.
Mike Robins was formally Senior Lecturer in Physiology at Kings College, London. "
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Table of contents

Detailed contents



Preface

Preface to the second edition

Preface to the first edition

Acknowledgements

Basic science, terminology and abbreviations



1. What is cancer?

Introduction

Carcinogenesis requires several cellular changes

Lifestyle and family influences on cancer

Changes continue to accumulate after cancer formation

Cancers are most common in epithelial cells

Cancer results from uncontrolled growth

Cancer genes

Invasion and metastasis

Some cancers are curable

Prevention, screening and treatment

Further reading

Websites



2. Natural history: the life of a cancer

Introduction

Clonal origins of cancer

Experimental biology

Box2.1: Special mice used in cancer research

Clinical data

Linking laboratory and clinic



3. Pathology: defining a neoplasm

Introduction

Box3.1: Classifying cancers

Histopathology

Cytology

Immunohistochemistry

Molecular techniques

Further reading



4. Epidemiology: identifying causes for human cancers

Introduction

Descriptive epidemiology

Box4.1: Epidemiological methods and terminology

Analytical epidemiology

Criteria required to establish causality

Biomarkers

Molecular epidemiology

Factors that influence human carcinogenesis

Cancer prevention

Further reading



5. Oncogenes, tumour suppressor genes and viruses

Introduction

Box5.1: Molecular terms relevant to genes and their regulation

Oncogenes

Tumour suppressor genes

Oncogenes and tumour suppressors cooperate

Further reading



6. Chemical and radiation carcinogenesis

Introduction

Chemical carcinogenesis

Radiation carcinogenesis

Consequences of DNA damage

Predicting the type of carcinogen by mutational spectrum analysis

Further reading



7. Mutations, DNA repair and genetic instability

Introduction

Mutations

Genetic instability

Types of DNA damage

Clinical evidence that links DNA repair and carcinogenesis

Repair mechanisms

Coordination of DNA repair, proliferation and apoptosis

Further reading



8. Familial cancers

Introduction

Box8.1: Chromosome nomenclature and structure

Strong familial link

Weaker familial link

Connection with sporadic cancers

Further reading



9. Growth: a balance of cell proliferation, death and differentiation

Introduction

Normal proliferation and its regulation

Box9.1: BNA synthesis and telomere length

Cancer cells

Senescence, cell mortality and telomerase

Cell death

Apoptosis and cancer

Integration of proliferation, apoptosis and DNA repair

Differentiation

Further reading



10. Responding to the environment: growth regulation and signal transduction

General features

Growth factors

Growth factor receptors

Growth factors: from membrane to nucleus

Nuclear events stimulated by growth factors

Cell adhesion molecules

Box10.1: How a cell interacts with its environment

Hydrophobic growth regulatory molecules

Cross-talk between signalling pathways

Further reading



11. Invasion and metastasis

Introduction

General features

Escape from local control and invasion

Intravasation

Angiogenesis

Gene changes involved in metastasis

Further reading



12. Principles of cancer treatment

Introduction

Principles behind the treatment of cancer

Chemotherapy

Hormone therapy

Immunotherapy/biological response modifier therapy

Photodynamic therapy

New forms of treatment

Further reading



13. Approaches to cancer prevention

Introduction

Breast cancer, tamoxifen and anastrozole

Endometrial/ovarian cancer and the contraceptive pill

Coloncancer and non-steroidal anti-inflammatory drugs

Diet

Further reading



Appendix: Features of selected cancers

Glossary

Index
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3 27% (3)
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