Bone Morphogenetic Proteins : Biological Characteristics and Role in Reconstructive Surgery
The discovery of a bone-inducing principle was paradoxically the result of a failed experiment intended to recalcify cortical bone. Using demineralized rabbit and rat bone matrix which was then implanted in muscle pouches, surprised researchers noticed that new cartilege and bone developed on or around the bone matrix surfaces. BMP is the generic name for the proteins extracted from bone matrix and the ability to extract these proteins has obvious research and clinical implications. This book covers research in bone morphogenetic proteins conducted from 1965 through 1995. Chapters range from immune response to regeneration of bone defect and focus on clinical treatment problems. Special reference is given to reconstructive repair, starting with clinical treatment of bone deficiencies. Features: * Covers the research conducted on bone morphogenetic proteins over the past 30 years. * Contains more than 70 illustrations. * Emphasis is placed on reconstructive repair, including clinical treatment of bone deficiencies.
- Hardback | 332 pages
- 184 x 259 x 23mm | 1,026g
- 01 Jun 1996
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
- 72 b&w illustrations, 6 colour illustrations
Table of contents
Thirty years of bone morphogenetic protein research, T.S. Lindholm et al; Bone morphogenetic protein in biology and medicine, M.R. Urist; Biochemical extraction, purification and characterization of native bone morphogenetic protein, L. Jortikka, A. Martinen; Recombinant bone morphogenetic proteins: cloning and molecular structures: K. Kostianen; Bone induction and immune occurrence in bone morphogenetic protein implantation, T.J. Gao; Target cells and receptors for bone morphogenetic protein, L. Jortikka; Bone inductivity of malignant bone neoplasms and cultured osteosarcoma cells, M. Laitinen; Bone morphogenic protein derived from osteosarcoma, K. Takaoka, H. Yoshikawa; Ectopic osteoinductive difference between purified bovine and recombinant human bone morphogenetic protein, K. Bessho; Bone morphogenetic protein and transforming growth factor-B, J.H. Wiklund; Searching for a novel carrier for bioactive delivery of bone morphogenetic protein, T.J. Gao, T.S. Lindholm; Bone morphogenetic proteins regenerating skull and maxillo-mandibular defects, T.C. Lindholm, V.V. Viljanen; Bone morphogenetic proteins and derivatives potentiate healing of segmental diaphyseal bone defects and non-union of fractures, T.J. Gao, T.S. Lindholm; Bone morphogenetic proteins and dentinogenesis, L.J. Yang, Y.H. Gao; Induction of cementogenesis and periodontal ligament regeneration by bone morphogenetic proteins, U. Ripamonti; Demineralized bone matrix inductive graft, K.J.J. Pajamaki, V.V. Viljanen; Purified bovine bone morphogenetic protein for clinical use in difficult conditions of cranio-maxillofacial surgery, H.F. Saller, E. Kolb; Experiences using native allogenic and xenogenetic bone morphogenetic protein in curing bone disturbances in domestic dogs, J. Oksanen, S. Paatsama; Clinical use of recombinant human bone morphogenetic protein-2 antibody in diagnosis of osteogenic lesions, K. Bessho.