Bone Cancer
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Bone Cancer : Progression and Therapeutic Approaches

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Description

The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches.

Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality.

Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases.
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Product details

  • Hardback | 504 pages
  • 218.44 x 276.86 x 30.48mm | 1,564.89g
  • Academic Press Inc
  • San Diego, United States
  • English
  • New ed.
  • Illustrations (some col.)
  • 012374895X
  • 9780123748959

Table of contents

Section 1: Introduction

Genetic control, frequencies and epidemiology of bone cancers

The incidence and progression of metastatic bone lesions

Section 2: Bone microenvironment and bone cancer

Bone microenvironment and tumor growth

Osteoblast Differentiation and Cell Signalling

Osteoclast Differentiation and Function

Cytokines in bone remodeling and bone tumors

Proteases and bone tumors - therapeutic approaches


Section 3: Bone markers

Early bone metastasis

Bone remodeling markers and bone cancer

Proteomic of bone cancers

Genomic Alterations in Bone Tumors

Biology of bone tumors and new diagnostic tools

Gene profiling of osteosarcoma

Molecular pathology of osteosarcoma

Histopathology of prostate and breast metastases

Technical aspects: how do we best prepare bone samples for proper histological analysis?


Section 4: Myeloma, odontogenic tumors and bone metastases

Multiple myeloma bone diseases

Osteolytic lesions

Bone metastases of prostatic cancer

Bone metastases of breast cancer

Section 5: Primary bone tumors

Osteosarcoma and osteoblasts: diagnosis and therapy

Ewing sarcoma family of tumors: diagnosis and therapy

Non-surgical treatment of chondrosarcoma: diagnosis and therapy

Chondrosarcoma of bone: diagnosis and therapy

Osteoclast-rich lesions of bone: diagnosis and therapy

Section 6: Imaging of bone cancers

Interventional Radiologic Techniques

Imaging of bone metastases

Diagnosis of bone metastases

Section 7: Pain control in bone cancers

Pain control with radiotherapy

Mechanisms and management of bone cancer pain

Malignant skeletal pain

Section 8: New therapeutic advances of bone cancers

Primary bone tumors and novel therapeutic approaches

Cytokine gene therapy in bone remodeling

Bisphosphonates

Multi-targeted approach

RANKL and targeted therapy

Apoptosis and drug resistance
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Review Text

"...Presents a comprehensive, translational source for all aspects of bone cancer in one reference work.Clear presentation...of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches."-- Anticancer Research , February 2015

"Reviewing the current advances in the progression and therapeutic approaches to bone cancer is an extremely challenging task. Bone cancer is not a single disease; rather, it is a field comprising a diverse and complex range of malignancies, from primary bone tumors of stromal cell origin, to hematopoietic malignancies and secondary metastatic bone disease. Dominique Heymann has assembled an exciting, comprehensive and up-to-date series of reviews contributed by experts in the basic and clinical aspects of bone research. In the past decade, our understanding of cancers involving bone has increased tremendously, underpinned by advances in the cellular, molecular and biochemical mechanisms of bone cell interactions in health and disease, together with advances in genetics, diagnostics, imaging and therapeutic strategies. All these aspects are covered in this timely volume, which will galvanize further cooperative efforts in the coming years between basic researchers, oncologists and pathologists towards understanding the causes of different bone cancers and translating this knowledge into the clinic."

-- Agi E. Grigoriadis, PhD, Departments of Craniofacial Development and Orthodontics, King's College London, United Kingdom

"Our understanding of bone biology and diseases has strikingly progressed in the last decade. In parallel, the processes that lead to various forms of cancer have been further unraveled and the mechanisms leading to metastatic spread further explored. In this book, Dr. Heymann has gathered some of the world experts on these subjects to explore the cutting edge where these fields merge in the context of bone cancer and metastasis, their pathophysiology, diagnosis and treatment. This encompassing book will undoubtedly meet the needs of residents and fellows as well as expert clinicians and scientists."

-- Roland Baron, Professor, Harvard Medical School, Boston MA, USA
"...Presents a comprehensive, translational source for all aspects of bone cancer in one reference work.Clear presentation...of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches."-- Anticancer Research , February 2015

"Reviewing the current advances in the progression and therapeutic approaches to bone cancer is an extremely challenging task. Bone cancer is not a single disease; rather, it is a field comprising a diverse and complex range of malignancies, from primary bone tumors of stromal cell origin, to hematopoietic malignancies and secondary metastatic bone disease. Dominique Heymann has assembled an exciting, comprehensive and up-to-date series of reviews contributed by experts in the basic and clinical aspects of bone research. In the past decade, our understanding of cancers involving bone has increased tremendously, underpinned by advances in the cellular, molecular and biochemical mechanisms of bone cell interactions in health and disease, together with advances in genetics, diagnostics, imaging and therapeutic strategies. All these aspects are covered in this timely volume, which will galvanize further cooperative efforts in the coming years between basic researchers, oncologists and pathologists towards understanding the causes of different bone cancers and translating this knowledge into the clinic."

-- Agi E. Grigoriadis, PhD, Departments of Craniofacial Development and Orthodontics, King's College London, United Kingdom

"Our understanding of bone biology and diseases has strikingly progressed in the last decade. In parallel, the processes that lead to various forms of cancer have been further unraveled and the mechanisms leading to metastatic spread further explored. In this book, Dr. Heymann has gathered some of the world experts on these subjects to explore the cutting edge where these fields merge in the context of bone cancer and metastasis, their pathophysiology, diagnosis and treatment. This encompassing book will undoubtedly meet the needs of residents and fellows as well as expert clinicians and scientists."

-- Roland Baron, Professor, Harvard Medical School, Boston MA, USA
show more

Review quote

"Reviewing the current advances in the progression and therapeutic approaches to bone cancer is an extremely challenging task. Bone cancer is not a single disease; rather, it is a field comprising a diverse and complex range of malignancies, from primary bone tumors of stromal cell origin, to hematopoietic malignancies and secondary metastatic bone disease. Dominique Heymann has assembled an exciting, comprehensive and up-to-date series of reviews contributed by experts in the basic and clinical aspects of bone research. In the past decade, our understanding of cancers involving bone has increased tremendously, underpinned by advances in the cellular, molecular and biochemical mechanisms of bone cell interactions in health and disease, together with advances in genetics, diagnostics, imaging and therapeutic strategies. All these aspects are covered in this timely volume, which will galvanize further cooperative efforts in the coming years between basic researchers, oncologists and pathologists towards understanding the causes of different bone cancers and translating this knowledge into the clinic."

-- Agi E. Grigoriadis, PhD, Departments of Craniofacial Development and Orthodontics, King's College London, United Kingdom

"Our understanding of bone biology and diseases has strikingly progressed in the last decade. In parallel, the processes that lead to various forms of cancer have been further unraveled and the mechanisms leading to metastatic spread further explored. In this book, Dr. Heymann has gathered some of the world experts on these subjects to explore the cutting edge where these fields merge in the context of bone cancer and metastasis, their pathophysiology, diagnosis and treatment. This encompassing book will undoubtedly meet the needs of residents and fellows as well as expert clinicians and scientists."

--Roland Baron, Professor, Harvard Medical School, Boston MA, USA
show more

About Dominique Heymann

Dominique Heymann studied cell biology, biochemistry and immunology in INSERM (French NIH) unit 211 at the University of Nantes and received his Ph.D. in 1995. He was appointed Associate Professor in 2001 in the Department of Histology and Embryology. In 2009, he was awarded a personal Chair of Histology and Embryology. Currently he is the Quality Control Manager of the Tissue Bank and Gene and Cellular Therapy Unit at Nantes Hospital. He heads a laboratory research group (INSERM UMR 957) of 65 people at the Faculty of Medicine, where the pathogenesis of primary bone tumours, and more specifically, the role of bone microenvironment (osteoclasts, mesenchymal stem cells, OPG/RANK/RANKL, IL-6 and MCSF cytokine family) in tumour growth is studied. In 2006, Dominique Heymann won the Paul Mathieu prize from the National Academy of Medicine for his work entitled "From the osteolytic process associated to primary bone tumors to the development of bi-therapies for osteosarcoma . He was on the national scientific advisory board of INSERM (2008-2012) and is now Co-Chairman of INSERM scientific commission n 5 ("Physiology and pathophysiology of endocrine, bone, skin and gastrointestinal tissues ). He has authored approximately 180 publications in peer- reviewed journals, more than 300 abstracts and 20 book chapters. He is also Associate Editor of Life Sciences, Academic Editor of PLoS ONE, Editor-in-Chief of the Open Bone Journal and serves on the Editorial Board of Current Medicine Chemistry, European Journal of Pharmacology, and Journal of Bone Oncology.
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