Biothermodynamics, Part C: Volume 488

Biothermodynamics, Part C: Volume 488

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In the past several years, there has been an explosion in the ability of biologists, molecular biologists and biochemists to collect vast amounts of data on their systems. Biothermodynamics, Part C presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions.

The use of thermodynamics in biological research is used as an "energy book-keeping system." While the structure and function of a molecule is important, it is equally important to know what drives the energy force. These methods look to answer: What are the sources of energy that drive the function? Which of the pathways are of biological significance?

As the base of macromolecular structures continues to expand through powerful techniques of molecular biology, such as X-ray crystal data and spectroscopy methods, the importance of tested and reliable methods for answering these questions will continue to expand as well.
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Product details

  • Hardback | 401 pages
  • 154.94 x 231.14 x 25.4mm | 839.14g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0123812682
  • 9780123812681

Table of contents

Measurement and Analysis of Equilibrium Binding Titrations: A beginner's guide
Dorothy Beckett

Macromolecular Competition Titration Method: Accessing Thermodynamics of the Unmodified Macromolecule - Ligand Interactions Through Spectroscopic Titrations of Fluorescent Analogs
Wlodzimierz Bujalowski and Maria J. Jezewska

Analysis of PKR-RNA interactions by sedimentation velocity
C. Jason Wong, Katherine Launer-Felty and James L. Cole

Structural and Thermodynamic Analysis of PDZ/Ligand Interactions
Tyson R. Shepherd and Ernesto J. Fuentes

Thermodynamic analysis of metal ion-induced protein assembly
Andrew B. Herr and Deborah G. Conrady

Thermodynamic Dissection of Colicin Interactions
Nicholas G Housden and Colin Kleanthous

Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling
John E. Ladbury and Stefan T. Arold

Structural and Functional Energetic Linkages in Allosteric Regulation of Muscle Pyruvate Kinase
J. Ching Lee and Petr Herman

Analysis of Free Energy versus Temperature Curves in Protein Folding and Macromolecular Interactions
Vince J. LiCata and Chin-Chi Liu

Application of the Sequential n-Step Kinetic Mechanism to Polypeptide Translocases
Aaron L. Lucius, Justin M. Miller and Burki Rajendar

A Coupled Equilibrium Approach to Study Nucleosome Thermodynamics
Andrew J. Andrews and Karolin Luger

Quantitative methods for measuring DNA flexibility in vitro and in vivo
Justin P. Peters, Nicole Becker, Emily M. Rueter, Zeljko Bajzer, Jason D. Kahna and L. James Maher

A Thermodynamic Approach for the Targeting of Nucleic Acid Structures Using Their Complementary Single Strands
Hui-Ting Lee, Caroline Carr, Hollie Siebler, Lela Waters, Irine Khutsishvili, Fany Iseka, Brian Domack, Chris M. Olsen, and Luis Marky

Thermodynamics of Biological Processes
Hernan G. Garcia, Jane Kondev, Nigel Orme, Julie Theriot and Rob Phillips

Protein stability in the presence of co-solutes
Luis Marcelo F. Holthauzen, Matthew Auton, Mikhail Sineva and Jorg Rosgen

Small Angle X-ray Scattering Studies of Peptide-Lipid Interactions using the Mouse Paneth Cell α-Defensin Cryptdin-4
Abhijit Mishra, Kenneth P. Tai, Nathan W. Schmidt, Andre J. Ouellette and Gerard C. L. Wong

Synergy of molecular dynamics and isothermal titration calorimetry in studies of allostery
Rebecca Strawn, Thomas Stockner, Milan Melichercik, Lihua Jin, Wei-Feng Xue, Jannette Carey and Rudiger Ettrich

Using tryptophan fluorescence to measure the stability of membrane proteins folded in liposomes
C. Preston Moon1 and Karen G. Fleming

Non-B Conformations of CAG Repeats Using 2-aminopurine
Natalya N. Degtyareva and Jeffrey T. Petty

Disulfide bond-mediated passenger domain stalling as a structural probe of autotransporter outer membrane secretion in vivo
Jonathan P. Renn & Patricia L. Clark

Strategies for the Thermodynamic Characterization of Linked Binding/Local Folding Reactions Within the Native State: Application to the LID Domain of Adenylate Kinase from Escherichia coli

Travis P. Schrank, W. Austin Elam, Jing Li and Vincent J. Hilser
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