The complete, fully updated introduction to biochemical and bioprocess engineering.
Bioprocess Engineering, Second Edition is a comprehensive update of the world's leading introductory textbook on biochemical and bioprocess engineering. Drs. Michael L. Shuler and Fikret Kargi review the relevant fundamentals of biochemistry, microbiology, and molecular biology, introducing key principles that enable bioprocess engineers to achieve consistent control over biological activity. This edition reflects powerful advances that are transforming the field, ranging from genetic sequencing to new techniques for producing proteins from recombinant DNA. It introduces techniques with broad application to the production of pharmaceuticals, biologics, and commodities; to medical applications such as tissue engineering and gene therapy; and for solving critical environmental problems. This new edition includes:
Essential biological basics: microorganism structure and functions, major metabolic pathways, enzymes, microbial genetics, kinetics, and stoichiometry of growthNew coverage of posttranslational processing of proteins-an essential technique for manufacturing therapeutic proteinsIn-depth coverage of animal cell culture processesNew coverage of noncarbohydrate metabolismFunctional genomics and cellular engineering: concepts, techniques, and applicationsApplying bioprocess engineering approaches to biomedical applicationsNonconventional biological systems applications, including host-vector systems for producing proteins from recombinant DNAExtensive coverage of mixed cultures, including advanced wastewater treatment processesExpanded coverage of modeling, including models in continuous cultures and cybernetic modelingHow the rapidly evolving governmental regulatory environment constrains bioprocess design and modification Bioprocess Engineering, Second Edition makes extensive use of illustrations, examples, and problems, and contains extensive references for further reading as well as a detailed appendix describing traditional bioprocesses.show more