Bioorganic Chemistry: Nucleic Acids

Bioorganic Chemistry: Nucleic Acids

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This work provides an overview of DNA and RNA including coverage of biosynthesis, stucture, and their functions in information storage and transmission. A review of fundamental material is presented in the first half of each chapter followed by a fairly detailed research example selected by the chapter author from current more

Product details

  • Hardback | 512 pages
  • 172.2 x 242.8 x 28.2mm | 1,000.26g
  • Oxford University Press Inc
  • New York, United States
  • English
  • New
  • halftones, numerous line figures, tables
  • 0195084675
  • 9780195084672

Back cover copy

Bioorganic Chemistry: Nucleic Acids, provides an overview of DNA and RNA, including coverage of biosynthesis, structure, and their functions in information storage and transmission. Special emphasis is given to the manner in which the individual chemistries of DNA and RNA conduce to their specific functions. The chemistry of molecules that disrupt nucleic acid biosynthesis and functions, antisense technologies involving RNA and DNA, and naturally occurring ribozymes are also covered. Each chapter begins with an introduction that includes basic principles, a summary of key findings which support current research in the field, and an overview of current research activity. The remainder of each chapter deals in greater detail with a number of recent studies that illustrate the nature of ongoing activity in the field. All chapters have been written by leading researchers, and numerous references are more

Table of contents

1. Fundamentals of Nucleic Acids ; 2. Chemical Synthesis of DNA/RNA ; 3. Enzymatic Methods for Preparation and Manipulation of Nucleic Acids ; 4. Structure of DNA and RNAM. ; 5. Chemical Mapping of Nucleic Acid Conformation ; 6. Introduction to 1H NMR Spectroscopy of DNA ; 7. The Formation of Alternative Structures in DNA ; 8. Reporter Groups for the Analysis of Nucleic Acid Structure ; 9. Nucleic Acid Binding and Catalysis by Metal Ions ; 10. Small Molecule-DNA Interaction ; 11. The Chemistry of Protein-DNA Interactions ; 12. Antisense/Antigene Oligonucleotides ; 13. Catalytic RNA ; 14. The Polymerase Chain Reaction and In Vitro Random Selectionshow more

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