Biology and Engineering of Stem Cell Niches
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Biology and Engineering of Stem Cell Niches

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Description

Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions.

The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro.

A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type.
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Product details

  • Paperback | 642 pages
  • 216 x 279 x 31.75mm | 1,720g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0128027347
  • 9780128027349

Table of contents

Part I. Biology of Stem Cell Niches and Molecular Mechanisms 1. The Need to Study, Mimic, and Target Stem Cell Niches 2. Harnessing the Biology of Stem Cells' Niche 3. Pluripotent Stem Cell Microenvironment 4. Regulation of Hematopoietic Stem Cell Dynamics by Molecular Niche Signaling 5. HSC Niche: Regulation of Mobilization and Homing 6. Neuronal Stem Cell Niches of the Brain 7. Cardiovascular Stem Cell Niche 8. Intestinal Epithelial Lgr5+ Stem Cell Niche and Organoids 9. The Epithelial Stem Cell Niche in Skin 10. The Satellite Cell Niche in Skeletal Muscle 11. The Cancer Stem Cell Niche 12. Cellular Senescence and Stem Cell Niche

Part II. Biochemical and Physical Cues in The Stem Cell Niche Directing Cell Fate 13. Matrix Chemistry Controlling Stem Cell Behavior 14. Matrix Growth Factor and Surface Ligand Presentation 15. Effect of Matrix Mechanical Forces and Geometry on Stem Cell Behavior 16. Wettability Effect on Stem Cell Behavior 17. Fluid Flow Control of Stem Cells With Investigation of Mechanotransduction Pathways 18. Hypoxia Regulation of Stem Cell: Mechanisms, Biological Properties, and Applications

Part III. Designing Smart Biomaterials to Mimic and Control Stem Cell Niche 19. Polymer Design and Development 20. Design and Development of Ceramics and Glasses 21. Surface Functionalization of Biomaterials 22. Biofunctional Hydrogels for Three-Dimensional Stem Cell Culture 23. Technologies to Engineer Cell Substrate Mechanics in Hydrogels 24. Micro- and Nanosurface Patterning Technologies 25. Self-Assembled Nanostructures (SANs) 26. Biomimetic Nanofibers as Artificial Stem Cell Niche

Part IV. Bioengineering Strategies to Model Synthetic Stem Cell Niches 27. Employing Microfluidic Devices to Induce Concentration Gradients 28. Engineering Niches for Embryonic and Induced Pluripotent Stem Cells 29. Engineering Niches for Cardiovascular Tissue Regeneration 30. Engineering Niches for Blood Vessel Regeneration 31. Engineering Niches for Bone Tissue Regeneration 32. Engineering Vascular Niche for Bone Tissue Regeneration 33. Engineering Niches for Cartilage Tissue Regeneration 34. Engineering Niches for Stem and Progenitor Cell Differentiation Into Immune Cells 35. Engineering Niches for Skin and Wound Healing 36. Designing Stem Cell Niche for Liver Development and Regeneration 37. Engineering the Niche for Intestinal Regeneration
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About Ajaykumar Vishwakarma

Dr Ajaykumar Vishwakarma works for the Division of Engineering in Medicine, Department of Medicine, at Brigham and Women's Hospital, as well as the Harvard-MIT Division of Health Sciences and Technology at the Massachusetts Institute of Technology. He graduated from Maharashtra University of Health Science, India with a B.D.S degree and has been a recipient of the Stem Cell Training Fellowship at Centre for Cellular and Molecular Biology. He completed his MSc in Tissue Engineering and PG Certificate in Biomedical Techniques from Cardiff University, UK. Additionally, he has held key industrial positions in the past to gain experience in commercialization and translational biotechnology. Dr. Vishwakarma's areas of specialization include innovation using bioengineering design principles to develop advanced therapeutic and non-therapeutic tissue engineered products for healthcare and to improve sustainability. His primary research addresses understanding the physical and biochemical properties of the extracellular matrix (ECM) and further designing cell-instructive biomaterials using micro- and nano-scale technologies to model synthetic somatic or stem cell niches in tissue regeneration. Specific focus is on vascularization, immunomodulation, bone, cartilage and tumors. Dr. Jeff Karp is a leading researcher in the fields of stem cell therapeutics, drug delivery, medical devices,and tissue adhesives. He is an Associate Professor at Brigham and Women's Hospital, Harvard Medical School, Principal Faculty at the Harvard Stem Cell Institute, and an affiliate faculty at the Broad Institute and at the Harvard-MIT Division of Health Sciences and Technology (where he teaches to MIT-Sloan business school students). He has published >100 peer-reviewed papers (with >11,750 citations) and has given 250 national and international invited lectures and has 65 issued or pending patents. Several technologies developed in his lab have formed the foundation for multiple products on the market and currently under development and for the launch of four companies including Skintifique, Gecko Biomedical, Alivio Therapeutics, Frequency Therapeutics. Karp's work has been discussed in hundreds of newspapers, online websites, television newscasts, and radio shows around the world including CNN, ABC News, NBC, Boston Globe, LA Times, BBC, Discovery, National Geographic, The Atlantic, The Guardian, American Museum for Natural History, Popular Mechanics, CTV Canada AM. Karp has also appeared multiple times on CBC's Quirks and Quarks and NPR Science Fridays. The Boston Business Journal recognized him as a Champion in Healthcare Innovation and MIT's Technology Review Magazine (TR35) also recognized Dr. Karp as being one of the top innovators in the world (3 members from his laboratory have subsequently received this award). His work has been selected by Popular Mechanic's "Top 20 New Biotech Breakthroughs that Will Change Medicine." He gave a TEDMED talk at the Kennedy Center in DC on bioinspired medical innovation and since 2015 has been a member of the TEDMED Editorial Advisory Board (only member to be elected to the board 3 years in a row). In 2015 and 2016 he received Breakthrough Awards from the Kenneth Rainin Foundation and in 2015 was a commencement speaker in at the University of Toronto. He also serves as a consultant to the Kenneth Rainin Foundation and the Crohn's and Colitis Foundation on the topic of new technologies for Inflammatory Bowel Disease. He has deep consulting expertise with startups and with several Fortune 500 companies across a wide spectrum of areas including drug delivery, medical devices, consumer healthcare products, and stem cell therapeutics. Dr. Karp was selected as the Outstanding Faculty Undergraduate Mentor among all Faculty at MIT and he received the HST McMahon Mentoring award for being the top mentor of Harvard-MIT students. To date, 18 trainees from his laboratory have secured faculty positions and several have transitioned into impactful careers in pharma, biotech, medtech, and venture capital.
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