Biological Science, Vol 1, Cell/Genetics

Biological Science, Vol 1, Cell/Genetics

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For courses in general biology for majors.Infused with the spirit of inquiry, Freeman, Biological Science helps teach students the fundamentals while introducing them to the excitement that drives the science. By presenting unifying concepts and methods of analysis, Biological Science helps students learn to think like a biologist and gives them the tools they need for success in upper-division coursesshow more

Product details

  • Paperback | 425 pages
  • 228.6 x 274.3 x 17.5mm | 1,147.6g
  • Pearson Education (US)
  • Pearson
  • United States
  • English
  • 0130932051
  • 9780130932051

Table of contents

1. Biology and the Tree of Life. The Cell Theory. The Theory of Evolution by Natural Selection. The Tree of Life. Biological Science.Box 1.1: Scientific Names and Terms.Box 1.2: Medicine, Economics and the Tree of Life.Essay: Where Do Humans Fit on the Tree of Life?UNIT I. THE ORIGIN AND EARLY EVOLUTION OF LIFE. 2. The Atoms and Molecules of Ancient Earth. The Ancient Earth. The Building Blocks of Chemical Evolution. Chemical Reactions, Chemical Energy, and Chemical Evolution. The Composition of the Early Atmosphere: Redox Reactions and the importance of Carbon. The Early Oceans and the Properties of Water.Box 2.1: Atomic Mass.Box 2.2: Bond Types Form a Continuum.Essay: The Search for Extraterrestrial Life.3. Macromolecules and the RNA World. The Start of Chemical Evolution: Experimental Simulations. The Building Blocks of Macromolecules. The First Macromolecules. The First Living Entity.Box 3.1: How Do Biologists Define Life?Box 3.2: Gel Electrophoresis and Autoradiography.Box 3.3: How Proteins Catalyze Reactions.Box 3.4: Models in Biology: The Double Helix.Essay: Molecular Handedness and the Thalidomide Tragedy.4. Membranes and the First Cells. Lipid Chemistry. Phospholipid Bilayers. Why Molecules Move Across Lipid Bilayers: Diffusion and Osmosis. Membrane Proteins.Box 4.1: The Transmission Electron Microscope.Box 4.2: The Scanning Electron Microscope.Box 4.3: The Fluid-Mosaic Model.Essay: The Molecular Basis of Cystic Fibrosis.UNIT II. CELL FUNCTIONS. 5. Cell Structure and Function. A Tour of the Cell. The Nucleus of Nuclear Transport. The Endomembrane System: Synthesis and Distribution of Cellular Products. The Cytoskeleton.Box 5.1: An Introduction to Centrifugation.Essay: Organelles and Human Disease.6. Respiration and Fermentation. An Overview of Cellular Respiration. Glycolysis. The Krebs Cycle. Electron Transport and Chemiosmosis. Fermentation. How Does Cellular Respiration Interact with Other Metabolic Pathways.Essay: ATP Production During Exercise.7. Photosynthesis. What Is Photosynthesis? How Does Chlorophyll Capture Light Energy? The Photosynthetic Reaction Centers. The Calvin Cycle.Box 7.1: Types of Plastids.Box 7.2: Why Was the Oxygen Revolution Important?Essay: Are Rising CO2 Levels in the Atmosphere Affecting Plant Productivity.8. Cell Division. Mitosis and the Cell Cycle. How Does Mitosis Take Place? Control of the Cell Cycle. Cancer: Out-of-Control Cell Division.Box 8.1: Cell-Culture Methods.Box 8.2: Cell Division in Bacteria.Essay: Cancer Chemotherapy.UNIT III. GENE STRUCTURE AND EXPRESSION. 9. Meiosis. How Does Meiosis Occur? The Consequences of Meiosis? Why Does Meiosis Exist? Why Sex? Mistakes in Meiosis.Box 9.1: Karyotyping Techniques.Box 9.2: Experimental Evidence for Physical Exchange of Chromosome Segments During Crossing Over.Box 9.3: Recombination in Bacteria.Essay: Seedless Fruits.10. Mendel and the Gene. Mendel's Experiments with a Single Trait? Mendel's Experiments with Two Traits. The Chromosome Theory of Inheritance. Testing and Extending the Chromosome Theory. Extending Mendel's Rules.Box 10.1: Combining Probabilities.Box 10.2: Sample Size and Chance Fluctuations.Essay: Does "Genetic Determinism" Exist?11. How Do Genes Work? DNA as the Hereditary Material. What Do Genes Do? The Genetic Code? The Central Dogma of Molecular Biology.Box 11.1: RNA Genomes: Exceptions to the Central Dogma.Essay: How Do Viruses Work?12. DNA Synthesis, Mutation, and Repair. Testing Early Hypotheses About DNA Replication. A Comprehensive Model for DNA Synthesis. Analyzing DNA Sequences in the Laboratory. The Molecular Basis of Mutation. Repairing Damaged DNA.Essay: The Genetic Basis of Cancer.13. Transcription and Translation. Transcription in Bacteria. Transcription in Eukaryotes. An Introduction to Translation. The of Transfer RNA. The Ribosome. Post-Transitional Events.Box 13.1: An Introduction to X-Ray Crystallography.Box 13.2: Prions.Essay: Transcription, Translation, and Toxins.14. Control of Gene Expression in Bacteria. Gene Regulation and Information Flow. Identifying the Genes Involved in Lactose Metabolism. The Discovery of the Repressor. Catabolite Repression and Positive Control. The Operator and the Repressor-An Introduction to DNA-Binding Proteins.Box 14.1: Gene Transfer in Bacteria.Box 14.2: Negative Control and Attentuation in the trp Operon.Box 14.3: DNA Footprinting.Essay: Controlling the Expression of Disease-Causing Genes.15. Control of Gene Expression in Eukaryotes. Mechanisms of Gene Regulation-An Overview. Eukaryotic DNA and the Regulation of Gene Expression. Regulatory Sequences in DNA. Regulatory Proteins. Post-Transcriptional Processing. Linking Cancer with Defects in Gene Regulation.Box 15.1: Recombinant DNA Technology.Box 15.2: Southern Blotting.Essay: Gene Regulation and the Green Revolution.16. Genomes. An Introduction to Whole-Genome Sequencing. Bacterial and Archaeal Genomes. Eukaryotic Genomes. Future Prospects.Box 16.1: Bioinformatics.Essay: Genomics and Issues of Privacy.17. Genetic Engineering and Its Applications. Using Recombinant DNA Techniques to Manufacture Proteins: The Effort to Cure Pituitary Dwarfism. Gene Hunting Based on Pedigree Analysis. Can Gene Therapy Cure Inherited Diseases in Humans? Biotechnology in Agriculture.Box 17.1: Genome Sequencing and Gene Hunting.Box 17.2: Genetic Testing.Essay: Controversies over Genetically Modified Foods.UNIT IV. DEVELOPMENTAL BIOLOGY. 18. An Introduction to Development. Developmental Stages and Patterns. Does the Genetic Makeup of Cells Changes as Development Proceeds? What Causes Differential Gene Expression?Essay: Human Cloning.19. Early Development. Gametogenesis. Fertilization. Cleavage. Gastrulation.Box 19.1: Visualizing mRNAs by Situ Hybridization.Essay: Treating Human Infertility.20. What Determines a Cell's Fate? Pattern Formation in Drosophila. Pattern Formation in Arabidopsis. Differentiation: Becoming a Specialized Cell. Box 20.1: Maternal Effect Inheritance.Box 20.2: Programmed Cell Death.Essay: Human Stem Cells. Appendix. Glossary. Index. Appendix. Glossary. Index.show more

About Scott Freeman

Scott Freeman received his Ph.D. in Zoology from the University of Washington and was nominated for an Excellence in Teaching Award in 1989. He was subsequently awarded an Albert Sloan Postdoctoral Fellowship in Molecular Evolution at Princeton University to investigate how generation time affects the rate of molecular evolution. Dr. Freeman's research publications explore a range of topics from the behavioral ecology of nest parasitism to the molecular systematics of the blackbird family. As an affiliate faculty member at the University of Washington, he has taught courses in evolution and has played an active role in the redesign of the general biology course. He is currently teaching the majors general biology course using an inquiry-based approach that emphasizes the logic of experimental design and the mastery of core concepts required for success in upper-level courses. Dr. Freeman is the co-author of Evolutionary Analysis, which presents evolutionary principles in the same spirit of inquiry that drives research.show more

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22 ratings
4.18 out of 5 stars
5 36% (8)
4 50% (11)
3 9% (2)
2 5% (1)
1 0% (0)
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