Biological Markers in Epidemiology

Biological Markers in Epidemiology

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This book provides an overview of the different types of biological markers, the epidemiologic issues that markers can address, and constraints associated with marker use. A discussion of marker properties presents issues to consider when selecting markers for a study and some approaches for evaluating marker properties are described. The majority of the book gives detailed reviews of several markers of particular importance to cancer epidemiology. Examples include urine mutagenesis, adducts, cytogenetic markers, oncogenes, and markers of susceptibility. Although the marker-specific chapters emphasize cancer, the overview sections discuss markers in general with illustrations from a variety of epidemiologic research areas. No other book on biological markers has been written for an epidemiologist audience. The book synthesizes diffuse information found primarily in the toxicology literature. It also provides a comprehensive introduction to markers for researchers without prior knowledge of markers, and particularly for epidemiologists. The reader need only have a basic knowledge of biology and more

Product details

  • Hardback | 248 pages
  • 150 x 230 x 19mm | 612g
  • Oxford University Press Inc
  • New York, United States
  • English
  • line figures and tables throughout
  • 0195059840
  • 9780195059847

Table of contents

Hulka: Overview; Wilcosky: Applications of biological markers; Wilcosky: Criteria for selecting and evaluating markers; Rynard: Urine mutagenicity assays as indicators of mutagenic exposures; Goldring & Lucier: Protein and DNA adducts; Wilcosky & Rynard: Sister chromatid exchanges; Vine: Micronuclei as indicators of exposure and response to genotoxic agents; Schwartz: Chromosome aberrations as exposure markers in epidemiologic studies; Schwartz: Oncogenes: a primer for epidemiologists; Vine & McFarland: Markers of susceptibility; Hulka: Methodologic issues in molecular epidemiology; Glossary of terms; more