Biological Consequences of Oxidative Stress

Biological Consequences of Oxidative Stress : Implications for Cardiovascular Disease and Carcinogenesis

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Oxygen radicals are highly reactive forms of oxygen that upset the body's normal chemistry. They are created by the reaction of oxygen with radiation, air pollution and other environmental agents, or generated in metabolism by one-electron transfers to an unstable oxygen molecule. Reactive species of oxygen and the damage they cause have been implicated in a variety of diseases. This volume focuses on their possible role in cardiovascular disease and cancer. It examines the molecular mechanisms by which oxidative damage occurs, the consequences of that damage, and some of the ways in which the damage might be mitigated. The book is based on a study group sponsored by the Conte Institute for Environmental Health, Pittsfield, Massachusetts, more

Product details

  • Hardback | 208 pages
  • 152.4 x 228.6 x 25.4mm | 628.22g
  • Oxford University Press Inc
  • New York, United States
  • English
  • line illustrations throughout
  • 0195072960
  • 9780195072969

Table of contents

L. Spatz: Introduction; R. Mason: Free radical metabolites of toxic chemicals and drugs as sources of oxidative stress; R. Korthuis, D. Carden & D.N. Granger: Cellular dysfunction induced by ischemia/reperfusion: role of reactive oxygen metabolites and granulocytes; G.M. Chisolm: The oxidation of lipoproteins: implications for atherosclerosis; S. Linn: DNA damage and stress responses due to oxygen radicals; N.H. Colburn: Gene regulation by active oxygen and other stress inducers: role in tumor promotion and progression; R.G. Stevens & K. Neriishi: Iron and oxidative damage in human cancer; T.W. Kensler & K.Z. Guyton: Modulation of carcinogenesis by more