The Biological Basis of Early Human Reproductive Failure

The Biological Basis of Early Human Reproductive Failure : Applications to Medically-assisted Conception

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This book explains how biological factors can influence the development of human gametes and early embryos, and how clinicians and researchers can use this information to select methods of medically-assisted conception best suited to infertile patients. Because laboratory methods and clinical protocols, such as the quality of water and purity used in culture medium, are essential to the success of laboratory-assisted conception, there is a tendency to give the inherent biology of gametes and embryos less weight in explaining the success or failure in achieving pregnancy. The book will redress the balance, and show how molecular, cellular, generic, endocrinological, and immunological factors contribute to the developmental potential of human gametes and early embryos. Reproductive biologists and clinicians involved in medically-assisted conception will find the book extremely useful. The authors are clinicians in medically-assisted conception and researchers in the etiology of early reproductive failure. They offer advice on how programmes could benefit from adopting analytical methods that would determine fertility/developmental problems at the gamete level. The ability to recognise how these intrinsic factors can affect the early stages of human development provides greater insights for interpreting pregnancy outcome, and a more complete understanding of the factors that can and cannot be controlled in attempts at medically-assisted more

Product details

  • Hardback | 464 pages
  • 156 x 234 x 28mm | 950g
  • Oxford University Press Inc
  • New York, United States
  • English
  • numerous black and white photographs, line drawings and tables
  • 0195060369
  • 9780195060362

Table of contents

Introduction: Intrinsic factores affecting the outcome of laboratory-assisted conception in the human; 1. The prognostic value of clinical factors in In Vitro fertilization and gamete intrafallopian transfer; 2. Endocrinological aspects of early pregnancy associated with reproductive success and failure; 3. The immunological basis of human gamete dysfunction and early developmental failure; 4. Detection of human sperm pathology by fine structural analysis; 5. The biochemistry and physiology of human spermatozoa: Consequences for fertility and sterility; 6. Developmental failure in human reproduction associated with chromosomal abnormalities and cytoplasmic pathologies in meiotically-mature oocytes; 7. Developmental failure during the preimplantation period of human embryogenesis; 8. Genetic defects in the human preimplantation embryo and the diagnosis of inherited disease; 9. Embryo-derived and maternal factors associated with developmental potential and viability of preimplantation mammalian embryos; 10. Factors influencing human embryonic developmentshow more