The Biological Basis of Drug Tolerance and Dependence

The Biological Basis of Drug Tolerance and Dependence

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A book intended for research workers, graduate/third year undergraduate students in neuroscience and pharmacology and interested research clinicians. This volume provides comprehensive reviews of the cellular and molecular mechanisms underlying tolerance to, and dependence upon, a wide spectrum of psychotropic drugs of abuse. The common neuroanatomical pathways involved, and the adaptive processes that occur at the receptor level, are discussed, together with how such features relate to the clinical problem. This is the third in the "Neurosciences Perspectives" and in common with the aims of the series provides up-to-date reviews of its topical subject from the biochemical and pharmacological points of view, with the historical perspective and prospects for clinical application.
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Product details

  • Hardback | 368 pages
  • 149.86 x 231.14 x 63.5mm | 566.99g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0125642504
  • 9780125642507

Table of contents

Psychotropic drug tolerance and dependence - common underlying mechanisms, J. Pratt; clinical features of drug tolerance and dependence, D. Nutt et al; biochemical and electophysiological mechanisms underlying benzodiazepine tolerance and dependence, D.W. Gallanger et al; the neurochemical mechanisms underlying nicotine tolerance and dependence, K.J. Balfour; ethanol tolerance and physical dependence - the role of calcium channels and other possible mechanisms, H. Little; opiod tolerance and dependence, B.M. Cox and L.L. Welling; psychomotor stimulants, F.J. White and M.E. Wolf; tolerance and dependence to psychotropic cannabinoids, R.W. Pertwee; the role of genetics in vulnerability to drug dependence, F.R. George et al.
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