Biologic Therapy of Leukemia

Biologic Therapy of Leukemia

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Description

Exciting new "biologic" therapies for treating leukemia are appearing so rapidly that clinicians often find it difficult to make informed decisions about their use when making patient treatment decisions. Biologic Therapy of Leukemia summarizes and reviews all the available data concerning these cutting-edge biologic therapies so that practicing clinicians can make the correct patient-care choices. Here the busy physician will find in one convenient place crucial information on the uses and limitations of the major biologic therapies for leukemia, the different biologic strategies for its treatment, the management of patients being treated with such biologic agents, and the current and future role of emerging biologic agents.
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Product details

  • Hardback | 270 pages
  • 156 x 234.2 x 26.7mm | 721.22g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • 2003 ed.
  • 24 Illustrations, black and white; XII, 270 p. 24 illus.
  • 1588290719
  • 9781588290717

Review quote

"...provides an in depth review of the biologic approaches that are entering the treatment arena for leukemia. The authors have done an excellent job of reviewing the current state of this therapeutic approach." - Medical Oncology
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Back cover copy

Exciting new "biologic" therapies for treating leukemia are appearing so rapidly that clinicians often find it difficult to make informed decisions about their use when making patient treatment decisions. In Biologic Therapy of Leukemia, distinguished physicians and medical researchers summarize and review all the available data concerning these cutting-edge biologic therapies so that practicing clinicians can make correct patient-care choices. Here the busy physician will find, in one convenient place, crucial information on the uses and limitations of the major biologic therapies for leukemia, the different biologic strategies for its treatment, the management of patients being treated with such biologic agents, and the current and future role of emerging biologic agents. Well-established therapies, such as interferon and all-trans-retinoic acid, are included so that their efficacy can be contrasted with such newer agents as imatinib mesylate and arsenic trioxide. P-glycoprotein inhibitors, interleukins, and the graft-vs-leukemia effect are also examined, along with approaches that reverse failure of apoptosis, alter genetic codes, and modulate immunologic mechanisms.
Authoritative and readily accessible, Biologic Therapy of Leukemia provides today's practicing oncologists with a comprehensive review of all currently available biologic approaches and agents, as well as the many different subtypes of leukemia, affording expert guidance in choosing optimal therapies for each patient.
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Table of contents

Part I: Immunotherapy

Human Leukemia-Derived Dendritic Cells as Tools for Therapy
David Claxton

The Graft vs Leukemia Effect
Brian J. Bolwell

Unconjugated Monoclonal Antibodies
Matt Kalaycio

Drug Immunoconjugate Therapy of Acute Myeloid Leukemia
Arthur E. Frankel, Bayard L. Powell, Eli Estey, and Martin S. Tallman

Radiolabeled Monoclonal Antibodies
John M. Burke and Joseph G. Jurcic

Part II: Cytokines

Interferons
Thomas Fischer

Interleukin-2 Treatment of Acute Leukemia
Peter Kabos and Gary J. Schiller

Part III: Targeted Therapeutics

Antisense Therapy
Stanley R. Frankel

Signal Transduction Inhibitors
Michael E. O'Dwyer and Brian J. Druker

P-Glycoprotein Inhibition in Acute Myeloid Leukemia
Thomas R. Chauncey

Targeting the Apoptotic Machinery as a Potential, Antileukemic Strategy
Benjamin M. F. Mow and Scott H. Kaufmann

Part IV: Differentiation Agents

Arsenicals: Past, Present, and Future
Chadi Nabhan and Martin S. Tallman

All-Trans-Retinoic Acid in the Treatment of Acute Promyelocytic Leukemia
Pierre Fenaux and Laurent Degos

Part V: Gene Therapy

Gene Therapy
Paul J. Orchard and R. Scott McIvor

Index
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