Bioimaging in Neurodegeneration
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Bioimaging in Neurodegeneration

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Bioimaging is in the forefront of medicine for the diagnosis and helps to predict the progression of AD via mild cognitive treatment of neurodegenerative disease. Conventional magnetic impairment (MCI) studies. resonance imaging (MRI) uses interactive external magnetic fields Novel neuroimaging technologies, such as neuromolecular and resonant frequencies of protons from water molecules. imaging (NMI) with a series of newly developed BRODERICK (R) However, newer sequences, such as magnetization-prepared rapid PROBE sensors, directly image neurotransmitters, precursors, acquisition gradient echo (MPRAGE), are able to seek higher and metabolites in vivo, in real time and within seconds, at separate levels of anatomic resolution by allowing more rapid temporal and selective waveform potentials. NMI, which uses an imaging. Magnetic resonance spectroscopy (MRS) images electrochemical basis for detection, enables the differentiation of metabolic changes, enabling underlying pathophysiologic neurodegenerative diseases in patients who present with mesial dysfunction in neurodegeneration to be deciphered. Neuro- versus neocortical temporal lobe epilepsy. In fact, NMI has some 1 chemicals visible with proton H MRS include N-acetyl aspartate remarkable similarities to MRI insofar as there is technological (NAA), creatine/phosphocreatine (Cr), and choline (Cho); NAA dependence on electron and proton transfer, respectively, and is considered to act as an in vivo marker for neuronal loss and/or further dependence is seen in both NMI and MRI on tissue neuronal dysfunction. By extending imaging to the study of composition such as lipids.
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Product details

  • Mixed media product | 314 pages
  • 218.4 x 284.5 x 22.9mm | 1,315.43g
  • Totowa, NJ, United States
  • English
  • 2005 ed.
  • XVI, 314 p. With CD-ROM.
  • 1588293912
  • 9781588293916

Back cover copy

New imaging sensors, molecular probes, and neuromarkers for faster temporal resolution, smaller spatial resolution, and higher anatomic accuracy have made brain neuroimaging highly valuable in studying neuropathologies. Provocative insights into how the human brain actually works in real time and in vivo are now possible. In Bioimaging in Neurodegeneration, prominent physicians, researchers, and inventors of cutting-edge technologies review the new imaging tools available for diagnosing, treating, and discovering the underlying causes of Parkinson's and Alzheimer's disease, epilepsy, and leukodystrophy. The new technologies demonstrated include novel sequences for magnetic resonance imaging (MRI), such as magnetization-prepared rapid acquisition gradient echo (MPRAGE); proton magnetic resonance spectroscopy (1H MRS); new tracers for positron emission tomography (PET) and single-photon emission tomography (SPECT), such as tropane analogs and altropane; neuromolecular imaging (NMI) of neurotransmitters directly in brain synapses of epilepsy patients with unique carbon-based electrochemical sensors; and intrinsic optical signal imaging (IOS), useful in diagnosing "spreading epileptiform depression." NMI and IOS also promise applications in intraoperative guided neurosurgery. Pediatric mitochondrial cytopathies are discussed, as well as nanotechnology, microtechnology, nanoimaging, and microimaging are presented. Devices for diagnosing tumors are also described. To enhance understanding of the potential of these developing technologies, a companion compact disk contains color versions of selected black-and-white illustrations used in the book.
Authoritative and state-of-the art, Bioimaging in Neurodegeneration offers both the physician and researcher a critical survey of the best new technologies for studying neurodegeneration, as well as describing their optimal use in the diagnosis and treatment of specific neurodegenerative diseases.
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Table of contents

Prologue: Nano- and Microimaging Surgical Anesthesia in Epilepsy Patients

I. Parkinson's Disease

Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in Parkinson's Disease: Structural vs Functional Changes
W. R. Wayne Martin

Positron Emission Tomography and Single-Photon Emission Tomography in the Diagnosis of Parkinson's Disease: Differential Diagnosis From Parkinson-Like Degenerative Diseases
Paul D. Acton

Positron Emission Tomography in Parkinson's Disease: Cerebral Activation Studies and Neurochemical and Receptor Research
Andre R. Troiano and A. Jon Stoessl

[123I]-Altropane SPECT: How It Compares to Other Positron Emission Tomography and Single-Photon Emission Tomography Dopamine Transporters in Early Parkinson's Disease
Hubert H. Fernandez, Paula D. Ravin, and Dylan P. Wint

Positron Emission Tomography and Embryonic Dopamine Cell Transplantation in Parkinson's Disease
Yilong Ma, Vijay Dhawan, Curt Freed, Stanley Fahn, and David Eidelberg

II. Alzheimer's Disease

Neurotoxicity of the Alzheimer's b-Amyloid Peptide: Spectroscopic and Microscopic Studies
David R. Howlett

Functional Imaging and Psychopathological Consequences of Inflammation in Alzheimer's Dementia
Jan Versijpt, Rudi A. Dierckx, and Jakob Korf

Neurotoxic Oxidative Metabolite of Serotonin: Possible Role in Alzheimer's Disease
Ladislav Volicer, Monika Z. Wrona, W. R. Wayne Matson, and Glenn Dryhurst

Predicting Progression of Alzheimer's Disease With Magnetic Resonance
Kejal Kantarci and Clifford R. Jack, Jr.

Stages of Brain Functional Failure in Alzheimer's Disease: In Vivo Positron Emission Tomography and Postmortem Studies Suggest Potential Initial Reversibility and Later Irreversibility
Stanley I. Rapoport

III. Epilepsy

Neocortical Epilepsy: a-Methyl-l-Tryptophan and Positron EmissionTomography Studies
Jun Natsume, Andrea Bernasconi, and Mirko Diksic

Pediatric Cortical Dysplasia: Positron Emission Tomography Studies
Bharathi Dasan Jagadeesan, Csaba Juhasz, Diane C. Chugani, and Harry T. Chugani

Bioimaging l-Tryptophan in Human Hippocampus and Neocortex: Subtyping Temporal Lobe Epilepsy
Steven V. Pacia and Patricia A. Broderick

In Vivo Intrinsic Optical Signal Imaging of Neocortical Epilepsy
Sonya Bahar, Minah Suh, Ashesh Mehta, and Theodore H. Schwartz

Intraoperative Magnetic Resonance Imaging in the Surgical Treatment of Epilepsy
Theodore H. Schwartz

Periodic Epileptiform Discharges Associated With Increased Cerebral Blood Flow: Role of Single-Photon Emission Tomography Imaging
Imran I. Ali and Noor A. Pirzada

Imaging White Matter Signals in Epilepsy Patients: A Unique Sensor Technology
Patricia A. Broderick and Steven V. Pacia

IV. Leukodystrophy (White Matter) Diseases

Overview of the Leukoencephalopathies: An MRI Point of View
Edwin H. Kolodny

Pyramidal Tract Involvement in Adult Krabbe's Disease: Magnetic Resonance Imaging and Proton Magnetic Resonance Spectroscopy Abnormalities
Laura Farina, Alberto Bizzi, and Mario Savoiardo

Imaging Leukodystrophies: Focus on Lysosomal, Peroxisomal, and Non-Organelle Pathology
Annette O. Nusbaum

Advanced Magnetic Resonance Imaging in Leukodystrophies
Edwin Y. Wang and Meng Law

Childhood Mitochondrial Disorders and Other Inborn Errors of Metabolism Presenting With White Matter Disease
Adeline Vanderver and Andrea L. Gropman

Mitochondrial Disease: Brain Oxidative Metabolism Studied by 31P, 1H, and 13C Magnetic Resonance Spectroscopy, Functional Magnetic Resonance Imaging, and Positron Emission Tomography
Graham J. Kemp

Index
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Review quote

"The editors have succeeded in creating a bridge between the molecular biology of important neurodegenrative disorders and advances in brain imaging." - Journal of Neurosurgery


"...highly recommended to readers who require a solid review and reference text on the state of the art in bioimaging in neurodegenrative diseases." - Annals of Neurology
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