Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors: Volume 95

Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors: Volume 95

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Description

Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson's disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson's disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.
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Product details

  • Hardback | 336 pages
  • 154.94 x 228.6 x 22.86mm | 566.99g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 94th edition
  • 0123813263
  • 9780123813268

Table of contents

Introductory remarks: Catechol-O-methyltransferase inhibition: an innovative approach to enhance L-dopa therapy in Parkinson's disease with dual enzyme inhibition
Erkki Nissinen

The catechol-O-methyltransferase gene, its regulation and polymorphisms
Elizabeth M. Tunbridge

Distribution and functions of catechol-O-methyltransferase proteins: do recent findings change the picture?
Timo T. Myoehanen & Pekka T. Mannistoe

Catechol-O-methyltransferase enzyme: Cofactor S-adenosyl-L-methionine and related mechanisms
Thomas Muller

Biochemistry and pharmacology of catechol-O-methyltrasferase inhibitors
Erkki Nissinen and Pekka T. Mannistoe

The Chemistry of Catechol-O-methyltransferase Inhibitors
David A. Learmonth, Laszlo E. Kiss and Patricio Soares-da-Silva

Toxicology and safety of COMT inhibitors
Kristiina Haasio

Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of the L-dopa treatment
Concepcio Marin, J.A. Obeso

Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinson's disease
Seppo Kaakkola

Catechol-O-methyltransferase and pain

Oleg Kambur & Pekka T. Mannistoe
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