Atypical Parkinsonian Disorders
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Atypical Parkinsonian Disorders : Clinical and Research Aspects

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A comprehensive review of what is known not only about the cause and treatment of atypical parksonian disorders, but also the issues that clinicians, researchers, patients, and caregivers face in dealing with them. The authors cover the basic science (history, epidemiology, genetics, pathology, nosology, computer modeling, and animal models), detailed clinical and laboratory assessments, and available diagnostic tools, including neuropsychiatric, neurologic, neuropsychologic, speech, electrophysiologic, and imaging evaluations. Current and future therapeutic approaches are also detailed, along with extensive discussions about future research directions.
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Product details

  • Mixed media product | 512 pages
  • 182.9 x 259.1 x 30.5mm | 1,451.51g
  • Totowa, NJ, United States
  • English
  • 2005 ed.
  • XX, 512 p. With online files/update.
  • 1588293319
  • 9781588293312
  • 2,578,291

Back cover copy

Despite an enormous amount of research in the past five years, our understanding of atypical parkinsonian disorders (APD) remains very much in its infancy. In Atypical Parkinsonian Disorders: Clinical and Research Aspects, a panel of highly knowledgeable and thoughtful investigators comprehensively reviews, for the first time, what is known not only about the cause and treatment of these devastating disorders, but also the issues that clinicians, researchers, patients, and caregivers face in dealing with them. The authors focus on progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy, dementia with Lewy bodies, and familial atypical parkinsonism, covering the basic science (history, epidemiology, genetics, pathology, nosology, computer modeling, and animal models), detailed clinical and laboratory assessments, and available diagnostic tools, including neuropsychiatric, neurologic, neuropsychologic, speech, electrophysiologic, and imaging evaluations. Current and future therapeutic approaches are also detailed, along with extensive discussions about future research directions.
Comprehensive and authoritative, Atypical Parkinsonian Disorders: Clinical and Research Aspects will enable clinicians to better diagnose, treat, and provide ongoing support for their parkinsonian patients, as well as provide researchers from all fields with encouragement and focus to pursue new research directions.
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Table of contents

What is an Atypical Parkinsonian Disorder?

Irene Litvan



Historical Issues and Atypical Parkinsonian Disorders

Christopher G. Goetz



Epidemiology of Progressive Supranuclear Palsy and Multiple System Atrophy

Adam Zermansky and Yoav Ben-Shlomo



Neuropathology of Atypical Parkinsonian Disorders

Ian R. A. Mackenzie



Animal Models of Tauopathies

Jada Lewis and Michael Hutton



Neurodegenerative a-Synucleinopathies

Michel Goedert and Maria Grazia Spillantini



Computer Modeling in Basal Ganglia Disorders

Jose Luis Contreras-Vidal



Atypical Parkinsonian Disorders: Neuropathology and Nosology

Charles Duyckaerts



Genetics of Atypical Parkinsonism: Implications for Nosology

Thomas Gasser



Medical History and Physical Examination in Parkinsonian Syndromes: How to Examine a Parkinsonian Syndrome

Marie Vidailhet, Frederic Bourdain, and Jean-Marc Trocello



Role of Neuropsychiatric Assessment in Diagnosis and Research

Dag Aarsland, Uwe Ehrt, and Clive Ballard



Added Value of the Neuropsychological Evaluation for Diagnosis and Research of Atypical Parkinsonian Disorders

Bruno Dubois and Bernard Pillon



Role of Praxis in Diagnosis and Assessment

Ramon Leiguarda



Role of Visuospatial Cognition Assessment in the Diagnosis and Research of Atypical Parkinsonian Disorders

Paolo Nichelli and Anna Magherini



Role of Ocular Motor Assessment in Diagnosis and Research

R. John Leigh and David S. Zee



Characterizing and Assessing Speech and Language Disturbances

Carol Frattali and Joseph R. Duffy



Quality of Life Assessment in Atypical Parkinsonian Disorders

Anette Schrag and Caroline E. Selai



Progressive Supranuclear Palsy

Irene Litvan



Corticobasal Degeneration: The Syndrome and the Disease

Bradley F. Boeve



Multiple System Atrophy

Felix Geser and Gregor K. Wenning



Clinical Diagnosis of Dementia With Lewy Bodies

David J. Burn, Urs P. Mosimann, and Ian G. McKeith



Clinical Diagnosis of Familial Atypical Parkinsonian Disorders

Yoshio Tsuboi, Virgilio H. Evidente, and Zbigniew K. Wszolek



Clinical Diagnosis of Vascular Parkinsonism and Nondegenerative Atypical Parkinsonian Disorders

Madhavi Thomas and Joseph Jankovic



Role of Electrophysiology in Diagnosis and Research in Atypical Parkinsonian Disorders

Josep Valls-Sole



Role of CT and MRI in Diagnosis and Research

Mario Savoiardo and Marina Grisoli



Role of Functional Magnetic Neuroimaging in Diagnosis and Research

Hartwig Roman Siebner and Gunther Deuschl



PET and SPECT Imaging in Atypical Parkinsonian Disorders

Alexander Gerhard and David J. Brooks



Current and Future Therapeutic Approaches

Elmyra V. Encarnacion and Thomas N. Chase



Rehabilitation of Patients With Atypical Parkinsonian Disorders

Daniel K. White, Douglas I. Katz, Terry Ellis, Laura Buyan-Dent, and Marie H. Saint-Hilaire



Overview and Future Research

Andrew Lees



Index
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Review Text

From the reviews:

"The present book is a comprehensive and updated review on APD by a large panel of international experts. ... Practical tables and diagrams and histopathological and MRI images are found throughout the book. ... an authoritative masterpiece that provides a large overview on these devastating disorders. ... This modern and comprehensive volume should be interesting for all neurologists and researchers interested in parkinsonian syndromes and other movement disorders." (Emmanuel Broussolle, European Neurology, April, 2006)
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Review quote

From the reviews:



"The present book is a comprehensive and updated review on APD by a large panel of international experts. ... Practical tables and diagrams and histopathological and MRI images are found throughout the book. ... an authoritative masterpiece that provides a large overview on these devastating disorders. ... This modern and comprehensive volume should be interesting for all neurologists and researchers interested in parkinsonian syndromes and other movement disorders." (Emmanuel Broussolle, European Neurology, April, 2006)
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