Astrocytes : Pharmacology and Function

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Interest in the functional roles of astrocytes in the nervous system has grown significantly as it is recognized that these cells not only have their own pharmacology but also release neuro- and vasoactive factors. This book relates astrocyte pharmacology to cell function which should make it an attractive text across the neuroscience community. The text discusses the pharmacological regulation of specific astrocyte functions; covers functional interactions between these and adjacent CNS cell types; examines regional heterogeneity of astrocytes with respect to receptor expression; and compares "in vitro" and "in vivo" approaches.
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Product details

  • Hardback | 485 pages
  • 158.75 x 230 x 25.4mm | 962g
  • Academic Press Inc
  • San Diego, United States
  • English
  • references
  • 0125113706
  • 9780125113700

Table of contents

Part 1 Astrocytes as target cells: astroglial adrenergic receptors, K. McCarthy, et al; amino acid receptors, B.R. Pearce; biochemical responses of astrocytes to neuroactive peptides, G.P. Wilkin and D.R. Marriott; astrocytes - targets and sources for purines, eicosanoids and nitrosyl compounds, G. Bruner, et al; early response gene expression signifying functional coupling of neuroligand receptor systems in astrocytes, A.T. Arenander and J. de Vellis; voltage-activated ionic channels in astrocytes, S. Duffy and B. MacVicar. Part 2 Astrocyte influences on neurons: astrocyte amino acids - evidence for release and possible interactions with neurons, G.R. Dutton; regulation of the brain microenvironment - transmitters and ions, H. Kimelberg, et al; neuropeptide expression in astrocytes, J.P. Schwartz; regulation of glycogen metabolism in astrocytes - physiological, pharmacological and pathological aspects, P.J. Magistretti, et al; astrocyte-derived neurotrophic factors, J.S. Rudge. Part 3 Interactions between astrocytes and with other cells in the CNS: astrocyte networks, A.M. Jensen and S-Y. Chiu; astrocyte-oligodendrocyte interactions, A.L. Gard; astrocyte-microglia interactions, E.N. Benveniste; interactions between astrocytes and endothelial cells in the central nervous system, P.A. Cancilla, et al; human astrocyte neoplasma, P.E. McKeever; metabolic disorders, M. Norenberg.
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