Aspirin and Related Drugs
Reviewing over a century of aspirin research and use, Aspirin and Related Drugs provides a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination, and future uses of aspirin.Highlighting the historical evolution of the salicylates and the commercial development of aspirin, the book reviews the pharmacokinetics of the salicylates, ibuprofen, and paracetamol as a basis for understanding the biodisposition of these analgesic drugs. Leading specialists discuss the therapeutic role of aspirin in the prevention and treatment of thrombo-embolic diseases, its place along with non-acetylated salicylates in the treatment of rheumatic diseases and plain, and the potential applications for aspirin and related drugs as prophylactics for colon cancer, Alzheimer's disease, and vascular dementia. They also present comparisons with other drugs used to treat pain and inflammation.With extensive data and literature covering a broad field, this is the definitive reference on the actions and applications of aspirin, salicylates, and related drugs. Physicians, pharmacists, pharmacologists, toxicologists, and chemists will find this resource useful in their daily work. It will also be valuable to pharmaceutical companies and researchers in the development of newer agents and novel applications.
- Hardback | 800 pages
- 170.2 x 251.5 x 48.3mm | 1,451.51g
- 01 Nov 2004
- Taylor & Francis Ltd
- London, United Kingdom
`Rainsford and co-writers do a superb job in detailing much of these lesser well-known actions of aspirin. The clinical studies with aspirin are presented exceptionally well and in great detail. The references following each chapter are the most comprehensive that I have seen. Parts of this book will find a very wide audience. Clinicians who use aspirin and related drugs should read some of the clinical chapters to see how little they know about the drugs they use. Research workers will find much here of interest, especially those with their heart in the right place who query prevailing dogmas. I would certainly have benefited from this book at the beginning of my research carrier and I would urge any and all PhD students working with anti-inflammatory drugs to dive into relevant chapters.'- Professor Ingvar Bjarnason, Professor of Digestive Diseases in the Department of Medicine, King's College London, for Journal of Pharmacy and Pharmacology, Volume 58, Issue 12, Page 1691, December 2006.
Table of contents
History and Development of the Salicylates, K.D. RainsfordThe Industrial History of Analgesics: The Evolution of Analgesics and Antipyretics, J.R. McTavishOccurrence, Properties and Synthetic Developments of the Salicylates, K.D. RainsfordPharmacokinetics and Metabolism of the Salicylates, G.G. Graham, M.S. Roberts, R.O. Day, and K.D. RainsfordMetabolism and Pharmacokinetics of Ibuprofen, G.G. Graham and K.M. WIlliamsPharmacokinetics and Metabolism of Paracetamol (Acetaminophen), G.G. Graham and M. HicksPharmacology and Biochemistry of Salicylates and Related Drugs, K.D. RainsfordSide-effects and Toxicology of the Salicylates, K.D. RainsfordReye's Syndrome and Aspirin, J.F.T. Glasgow and S.M. HallSalicylates in the Treatment of Acute Pain, K.D. RainsfordAcetysalicylic Acid for the Prevention and Treatment of Thromboembolic Diseases, K.E. Webert and J.G. KeltonUse of Salicylates in Rheumatic and Related Conditions, W.W. Buchanan, W.F. Kean, and K.D. RainsfordAspirin and NSAIDs in the Prevention of Cancer, Alzheimer's Disease and other Novel Therapeutic Actions, K.D. Rainsford