Applied Biopharmaceutics & Pharmacokinetics, Fifth Edition

Applied Biopharmaceutics & Pharmacokinetics, Fifth Edition

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The most comprehensive text on the practical applications of biopharmaceuticals and pharmacokinetics!

"The updated edition provides the reader with a solid foundation in the basic principles of pharmacokinetics and biopharmaceutics. Students will be able to apply the information to their clinical practice and researchers will find this to be a valuable reference. This modestly priced book should be the gold standard for student use."--Doody's Review Service

The primary emphasis of this book is on the application and understanding of concepts. Basic theoretical discussions of the principles of biopharmaceutics and pharmacokinetics are provided, along with illustrative examples and practice problems and solutions to help the student gain skill in practical problem solving.
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Product details

  • Hardback | 892 pages
  • 193 x 241 x 38mm | 1,475g
  • McGraw-Hill Medical
  • New York, United States
  • English
  • 5th edition
  • 0071375503
  • 9780071375504
  • 780,705

Back cover copy

The Best Way to Learn Biopharmaceutics and Pharmacokinetics. "Applied Biopharmaceutics and Pharmacokinetics" provides the reader with a basic understanding of the principles of biopharmaceutics and pharmacokinetics as applied to drug product development and drug therapy. The revised and updated fifth edition of this popular text remains unique in teaching the student the basic concepts that may be applied to understanding the complex issues associated with the processes of drug delivery and the essentials of safe and effective drug therapy. NEW TO THIS EDITION:
*Chapter on Pharmacogenetics
*Explanation of the role of pharmacogenetics in drug metabolism using examples of drugs that frequently lead to drug interactions
*Chapter on the Impact of Biopharmaceutics on Drug Product Quality and Clinical Efficacy
*Enhanced applications to pharmacy practice with the emphasis on biopharmaceutics, pharmacokinetics and drug delivery
*Updated coverage of dosing in clinical situations including dosing in special populations and what to do with a skipped dose in patients
*Additional practice problems and clinical examples
*Newest concepts in biopharmaceutics and pharmacokinetics
*Reorganized content to follow today's curriculum in pharmaceutical sciences " ... An excellent book on biopharmaceutics and pharmacokinetics ... recommended not only for the newcomer, but as a valuable reference in any library."
--Online reader review of the previous edition
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Table of contents

PrefaceGlossaryChapter 1 Introduction to Biopharmaceutics and Pharmacokinetics Chapter 2 Mathematic Fundamentals in Pharmacokinetics Chapter 3One Compartment Open Model - IV Bolus Injection Chapter 4Multicompartmental Models - IV Bolus InjectionChapter 5Intravenous InfusionChapter 6Drug Elimination and ClearanceChapter 7Pharmacokinetics of Oral AbsorptionChapter 8 Multiple Dosage RegimensChapter 9 Nonlinear PharmacokineticsChapter 10 Physiologic Drug Distribution and Protein BindingChapter 11 Renal and Hepatic Elimination of Drugs Chapter 12Pharmacogenetics - NEW Chapter 13Physiologic Factors Related to Drug AbsorptionChapter 14Biopharmaceutic Considerations in Drug Product DesignChapter 15Bioavailability and Bioequivalence Chapter 16 Impact of Biopharmaceutics on Drug Product Quality and Clinical Efficacy - NEW Chapter 17Modified Release Drug Products and Drug DevicesChapter 18Targeted Drug Delivery Systems and Biotechnology ProductsChapter 19Relationship between Pharmacokinetic and Pharmacodynamics Chapter 20Application of Pharmacokinetics in Clinical SituationsChapter 21 Dosage Adjustment in Renal and Hepatic Disease Chapter 22 Physiological Pharmacokinetic Models, Mean Resident Time and Statistical Moment TheoryAppendix AStatisticsAppendix BApplications of Computers in PharmacokineticsAppendix CEthical ConsiderationsAppendix DSolutions to Frequently Asked Questions (FAQ) and Learning QuestionsAppendix EPopular Drugs and Pharmacokinetic Parameters
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About Leon Shargel

Ph.D., R.Ph.President, Applied Biopharmaceutics, LLC, Raleigh, NCAffiliate Professor, School of Pharmacy, Virginia Commonwealth University, Richmond VAAdjunct Associate Professor, School of Pharmacy, University of Maryland, Baltimore, MD

McGraw-Hill authors represent the leading experts in their fields and are dedicated to improving the lives, careers, and interests of readers worldwide

Andy Yu, formerly a professor at the Albany College of Pharmacy, is currently with the FDA in Rockville, MD.
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103 ratings
4.16 out of 5 stars
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4 25% (26)
3 17% (17)
2 6% (6)
1 2% (2)
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