A book aimed at researchers, organic and medicinal chemists, biochemists, pharmacologists, and endocrinologists in academic, clinical, and industrial (pharmaceutical) settings. This book is both timely and comprehensive in its presentation of the link between state-of-the-art steroid chemistry and current understanding of tumour cells and their interactions with steroid-based molecules. It chronicles the use of naturally occurring steroids as well as synthetic modifications in the treatment of cancer. The book discusses the use of steroids to carry antitumour moieties to selected targets. It also discusses biochemical mechanisms, describes chemical syntheses, and provides structures. Topics covered include - steroids that are used clinically for cancer treatment; new compounds currently undergoing preclinical evaluation; synthetic approaches to antitumour compounds; attachment of antitumour moieties to steroids; and mechanisms of action where they are known.
- Hardback | 295 pages
- 158.75 x 230 x 19.05mm | 674g
- 01 Dec 1992
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
- references, indices
Table of contents
The role of steroids in cancer treatment; estrogens, antiestrogens, and other estrane compounds; androgens and other androstane derivatives; progestins and other pregnane derivatives; corticoids; sterols and cucurbitacins; vitamin D; cardenolides, bufadienolides and withanolides; bile acids, sapogenins, and miscellaneous steroids.