Antisense Therapeutics

Antisense Therapeutics

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Description

A timely primer on the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery. Highlights include RNA-based therapies for many diseases, up-to-date methods and applications, and insight into the enormous potential to provide a new generation of drugs.
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Product details

  • Hardback | 344 pages
  • 156 x 232 x 26mm | 662.26g
  • Totowa, NJ, United States
  • English
  • Revised
  • 2nd ed. 2005
  • 56 Illustrations, black and white; 344 p. 56 illus.
  • 1588292053
  • 9781588292056

Back cover copy

Announcement of the complete sequencing of the human genome in April 2003 demonstrated the presence of thousands of targets for antisense oligonucleotides and opened the way to hundreds of preclinical animal studies and some 20 ongoing clinical trials. In this second edition of Antisense Therapeutics, a team of leading researchers and clinical scientists demonstrate the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery. Highlights include RNA-based therapies for many diseases, up-to-date methods and applications, and insight into the enormous potential to provide a new generation of drugs.
Highly practical and disease oriented, Antisense Therapeutics, Second Edition offers not only a primer for a new generation of drug discovery researchers, but also an illuminating exploration of the potential in exploiting RNA inhibition for novel human therapeutics.
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Table of contents

Part I. Introduction

Antisense Therapeutics: A Promise Waiting to be Fulfilled
M. Ian Phillips

Antisense Inhibition: Oligonucleotides, Ribozymes, and siRNAs
Y. Clare Zhang, Meghan M. Taylor, Willis K. Samson, and M. Ian Phillips

Part II. Cardiovascular

Local Application of Antisense for Prevention of Restenosis
Patrick L. Iversen, Nicholas Kipshidze, Jeffrey W. Moses, and Martin B. Leon

Antisense Therapeutics for Hypertension: Targeting the Renin-Angiotensin System
M. Ian Phillips and Birgitta Kimura

Antisense Strategies for the Treatment of Heart Failure
Sian E. Harding, Federica del Monte, and Roger J. Hajjar

Part III. Cancer

Clinical Studies of Antisense Oligonucleotides for Cancer Therapy
Rosanne M. Orr and F. Andrew Dorr

Antisense Therapy in Clinical Oncology: Preclinical and Clinical Experiences
Ingo Tamm

Radionuclide-Peptide Nucleic Acid Diagnosis and Treatment of Pancreatic Cancer
Eric Wickstrom, Xiaobing Tian, Nariman V. Amirkhanov, Atis Chakrabarti, Mohan R. Aruva, Ponugoti S. Rao, Wenyi Qin, Weizhu Zhu, Edward R. Sauter, and Mathew L. Thakur

Suppression of Pancreatic and Colon Cancer Cells by Antisense K-ras RNA Expression Vectors
Kazunori Aoki, Shumpei Ohnami, and Teruhiko Yoshida

Induction of Tumor Cell Apoptosis and Chemosensitization by Antisense Strategies
Manuel Rieber and Mary Strasberg-Rieber

Utility of Antioncogene Ribozymes and Antisense Oligonucleotides in Reversing Drug Resistance
Tadao Funato

Part IV. Blood-Brain Barrier

Transport of Antisense Across the Blood-Brain Barrier
Laura B. Jaeger and William A. Banks

Part V. Dermal

Transdermal Delivery of Antisense Oligonucletoides
Rhonda M. Brand and Patrick L. Iversen

Part VI. Drugs

Antisense Strategies for Redirection of Drug Metabolism: Using Paclitaxel as a Model
Vikram Arora

Part VII. Gastrointestinal

Antisense Oligonucleotide Treatment of Inflammatory Bowel Diseases
Bruce R. Yacyshyn

Part VIII. Hepatitis

Optimizing Electroporation Conditions for the Intracellular Delivery of Morpholino Antisense Oligonucleotides Directed Against the Hepatitis C Virus Internal Ribosome Entry Site
Ronald Jubin

Index
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Review quote

From Reviews of the First Edition...



"...strongly recommended both to scientists already engaged in antisense research and to newcomers alike." -Trends in Biotechnology



"...enables an appreciation of the exciting possibilities this field offers for the development of new uniquely selective therapeutic agents via precisely designed inhibitors of the expression of disease associated genes." -Journal of Medicinal Chemistry



Reviews from the Second Edition...



"This book does an excellent job of showing the reader that antisense oligonucletoids could be valuable therapeutic drugs in the future." - Doody's Health Sciences Book
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