Antipsychotic Drugs and Their Side-effects

Antipsychotic Drugs and Their Side-effects

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In line with other volumes in neuroscience perspectives, this volume covers the background, pharmacology, molecular biology and biochemistry of antipsychotic drugs, together with an overview asssessment of the therapeutic considerations. The first half of this book addresses the basic science issues related to both the established and novel antipsychotic drugs. In addition to the pharmacology of these agents, there are chapters addressing the use of recent brain-imaging techniques in the investigation of antipsychotic drug action, the prediction of antipsychotic activity from preclinical models and discussion in the assessment of antipsychotic activity in clinical trials. The second half of the volume addresses the clinical use of antipsychotic agents, including the indication for their use, the clinical problems associated with their acute and chronic administration and the advantages and disadvantages of depot medication as maintenance treatment. The range of adverse effects associated with their drugs is also reviewed. This book reviews both the basic science of the conventional and atypical neuoleptics and their present and potential therapeutic use.
It brings together contributions from experts in the basic science and clinical science fields.
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Product details

  • Hardback | 204 pages
  • 157.7 x 235.7 x 23.9mm | 636.99g
  • Academic Press Inc
  • San Diego, United States
  • English
  • United States ed
  • 0120790351
  • 9780120790357

Table of contents

Part 1 Basic science: the pharmacology of the phenothiazines, butyrophones, thioxanthines and diphenylbutypiperidines, B.E. Leonard; the pharmacology of colzapine-like atypical antipsychotics, D.M. Coward; pharmacology and clinical properties of selective dopamine antagonists, with focus on substituted benzamides, J. Gerlach; pre- and post-synaptic D-1 to D-5 dopamine receptor mechanisms in relation to antipsychotic activity, J.L. Waddington; prediction of antipsychotic activity, N.J. Rupniak and S.D. Iversen; effects of neuroleptics on neuronal and synaptic structure, P.J. Harrison; brain imaging and antipsychotic drugs, P.F. Liddle; pharmocokinetics of antipsychotic drugs, S.H. Curry. Part 2 Clincal issues: the assessment of antipsychotic activity in clinical trials, S.R. Hirsch; indications of antipsychotic drugs, R.G. McCreadle; acute treatment, J.M. Kane; maintenance treatment; J.M. Davis et al; depot neuroleptics, D.A.W. Johnson; the side effects of antipsychotic drugs, II - effects on other physiological systems, J.G. Edwards and T.R.E. Barnes.
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