Antioxidants and Cardiovascular Medicine

Antioxidants and Cardiovascular Medicine

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This work addresses a complex problem in cardiovascular medicine. It is written by experts in the fields of atherosclerosis, heart failure, and antioxidants. It should be of interest not only to academicians but also to practising physicians, including postdoctoral fellows, internists, cardiologists, and general practitioners. The first three chapters review the antioxidant hypothesis and its close relationship to lipid mechanisms of action and classify the different and heterogeneous pharmacological compounds with known antioxidant properties, and describe the role of dietary nutrients and supplements as well as the potential therapeutic benefit of antioxidants in coronary artery disease prevention and risk reduction, prevention of endothelial dysfunction, and prevention of chronic heart failure. Finally, current knowledge of the use of these compounds in cardiovascular medicine is summarized.
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Product details

  • Hardback | 264 pages
  • 165.1 x 230 x 12.7mm | 612.35g
  • Dordrecht, Netherlands, United States
  • English
  • 079236564X
  • 9780792365648

Table of contents

List of Contributors. Preface by the editors. 1. Lipoproteins and Oxidation: Clinical Aspects of Lipoprotein Metabolism and Oxidation; H.R. Superko. 2. Pathogenesis of Artherosclerosis; R. Gallo, V. Fuster. 3. The Antioxidant Hypothesis; M. Forgione, J. Loscalzo. 4. Reactive Oxygen Species as Mediators of Signal Transduction in Cardiovascular Disease; J. Abe, B.C. Berk. 5. Pharmaceutical Compounds with Antioxidant Activity; A. Bast, G.R.M.M. Haenen. 6. Nutrition and Antioxidants; P. Rubba, M. Mancini. 7. Antioxidants and Vascular Disease: Animal Studies; J.F. Keaney, Jr. 8. Antioxidants and Endothelial Function - Human Studies; C. Bingelli, et al. 9. Antioxidant Vitamins and Cardiovascular Disease: Evidence from Observational Epidemiologic Studies and Randomized Trials; W.G. Christen, C.H. Hennekens. 10. A Rationale for Antioxidant Use in Cardiovascular Disease; R.P. Mason. 11. Antioxidants and Restenosis - Animal Studies; A. Lafont, et al. 12. Antioxidants and Restenosis - Human Studies; J.-C. Tardif, et al. 13. Role of Oxidative Stress, Cytokines and Apoptosis in Myocardial Dysfunction; D.B. Sawyer, W.S. Colucci. 14. Oxidative Stress and Use of Antioxidants in Patients with Congestive Heart Failure; M. White, et al. 15. Use of Antioxidants in Cardiovascular Medicine; J.L. Mehta, et al. Appendix. Update on Recently Completed Clinical Trials on Antioxidants and Cardiovascular Diseases; J.-C. Tardif, M.G. Bourassa. Index.
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