Antigenic Variation

Antigenic Variation

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The topic of antigenic variation is important in both biology and medicine. It is of enormous interest, as it describes the process(es) whereby microorganisms 'shift shape', by genetic rearrangement or otherwise. In medical terms, this has a major impact on the infectious disease process, since the immune system has great difficulty in keeping up with this variation, and thus eliminating the infectious agent. Antigenic variation is a major method by which microbes evade the immune response, and persist in the body.
The broad scope of the book appeals to all those working in the field of infectious disease, immunology of infection, pathogenesis, molecular biology and also to evolutionary biologists. Topics covered include not only bacterial species, and viruses such as influenza, HIV, Rotavirus, but also eukaryotic parasites - one of the most fascinating groups of organisms exhibiting this behaviour.
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Product details

  • Hardback | 464 pages
  • 156 x 234 x 25.4mm | 910g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 012194851X
  • 9780121948511

About Alister Craig

Edited by Alister G. Craig and Artur Scherf
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Review quote

"It provides an excellent review, drawing from examples as diverse as HIV...a useful addition to the bookshelf."
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Table of contents

Synthesis of allelic/antigenic variation
HIV variation - a question of signal-to-noise
Influenza, the chameleon virus
Haemophilus Influenzae
Phase Variation in Helicobacter pylori Lipopolysaccharide
Genetic Variation in the Pathogenic Neisseria Species
Candida Albicans
The MSG Gene Family and Antigenic Variation in the Fungus P. carinii
Trypanosome Antigenic Variation - a heavy investment in the evasion of immunity
Antigenic variation in Anaplasma marginale and Ehrlichia (Cowdria) ruminantium
Antigenic Variation and its' Significance to Babsesia
Antigenic Variation in Plasmodium falciparum and other Plasmodium
Antigenic Variation in Borrelia: Relapsing Fever and Lyme Borreliosis
Surface Antigenic Variation in Giardia lamblia
Free-living and Parasitic Ciliates:The Impact of Antigenic Variation on Pathogen Population Structure, Fitness and Dynamics
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